PMID: 2119496Sep 11, 1990Paper

The immunoglobulin M heavy chain constant region gene of the channel catfish, Ictalurus punctatus: an unusual mRNA splice pattern produces the membrane form of the molecule

Nucleic Acids Research
M R WilsonG W Warr

Abstract

The immunoglobulin (IgM) heavy chain constant region gene of the channel catfish, Ictalurus punctatus, has been cloned and characterized. The gene contains four constant region domain-encoding exons (CH1 to CH4) expressed in the secreted form of the immunoglobulin, and two exons encoding the transmembrane (TM) domain utilized in the lymphocyte membrane receptor form of the immunoglobulin. The sequence of a cDNA clone encoding the 3' region of the message for the membrane receptor form of the mu chain indicates that the TM1 exon is spliced directly to the CH3 exon, and not into a site within the CH4 exon, as occurs in the mammals, a shark and an amphibian. This unusual pattern of splicing, which produces a membrane heavy chain that is characteristically smaller than the secreted heavy chain, may be common to all teleost fish.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 1, 1977·Developmental and Comparative Immunology·G W Warr, J J Marchalonis
Sep 1, 1976·Nucleic Acids Research·N Blin, D W Stafford
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·G W WarrJ J Marchalonis
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C T Amemiya, G W Litman
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J SchwagerL A Steiner
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Jan 1, 1981·Immunological Reviews·L MorettaJ C Cerottini

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Citations

May 10, 1995·Molecular & General Genetics : MGG·Z IzsvákP B Hackett
Jan 1, 1995·Developmental and Comparative Immunology·G W Warr
Mar 1, 1995·Developmental and Comparative Immunology·M R WilsonG W Warr
Mar 1, 1995·Developmental and Comparative Immunology·M R WilsonG W Warr
Mar 1, 1994·Developmental and Comparative Immunology·F W van GinkelL W Clem
Aug 1, 1995·Immunology Today·G W WarrD A Higgins
Apr 1, 1993·Current Opinion in Immunology·L Du Pasquier
Jan 5, 2002·Developmental and Comparative Immunology·Richard N MorrisonBarbara F Nowak
Jun 12, 2003·Developmental and Comparative Immunology·Linling ShenNorman W Miller
Sep 1, 1996·Developmental and Comparative Immunology·M A RycyzynN W Miller
Nov 1, 1996·Veterinary Immunology and Immunopathology·M F Flajnik
Jun 6, 2003·Fish & Shellfish Immunology·Ikuo HironoTakashi Aoki
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·Z IvicsP B Hackett
Jun 1, 1993·Avian Pathology : Journal of the W.V.P.A·D A Higgins, G W Warr
May 13, 1999·Immunological Reviews·M F FlajnikM Nonaka
Jun 8, 1999·Annual Review of Immunology·G W LitmanJ P Rast
Aug 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yaofeng ZhaoLennart Hammarström
Jul 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yuko Ohta, Martin Flajnik
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·M WilsonG W Warr
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nadia Danilova, Lisa A Steiner
Apr 15, 1994·Annals of the New York Academy of Sciences·T MatsunagaE Andersson
Oct 9, 2012·Developmental and Comparative Immunology·R Craig FindlyHarry W Dickerson
Nov 17, 2010·Developmental and Comparative Immunology·Jun-ichi HikimaTakashi Aoki
Jul 28, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Bergljot MagnadottirSigurdur Helgason
Dec 2, 2008·Molecular Immunology·Mara L Lennard RichardGregory W Warr
Nov 26, 2008·Developmental and Comparative Immunology·Mats LundqvistPierre Boudinot
Aug 5, 2008·Veterinary Immunology and Immunopathology·Mohadetheh MoulanaThomas J McConnell
Jun 24, 2008·Developmental and Comparative Immunology·Manoranjan SahooMelanie Wilson
Nov 3, 2010·Developmental and Comparative Immunology·Yu-Lan HuJian-Zhong Shao

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