The immunohistochemical analysis of RCAS1, HLA-G, and B7H4-positive macrophages in partial and complete hydatidiform mole in both applied therapeutic surgery and surgery followed by chemotherapy

American Journal of Reproductive Immunology : AJRI
Pawel BastaLukasz Wicherek

Abstract

The suppressive microenvironment developing around the implantating ovum in normal pregnant women may correlate with the development in cancer patients of a suppressive microenvironment of neoplasmatic cells derived from trophoblasts, such as occurs in molar lesions. Macrophages are suitable candidates for mediating not only the balance of the maternal defensive immune responses to external antigens, but also a tolerance to tumor cells. The aim of our study has been to gain information about the expression of RCAS1, B7H4, and HLA-G within the macrophages present in the microenvironment of the molar lesion. We analyzed the immunoreactivity of such antigens as B7H4, RCAS1, and HLA-G on the macrophages present in tissue samples derived from patients on whom curettage was performed after a diagnosis of molar pregnancy. These patients were then divided into two subgroups according to whether or not they required chemotherapy after the surgical procedure. We observed a statistically significant increase in the RCAS1-positive macrophage infiltration within the microenvironment of the molar lesions in patients with partial hydatidiform mole in comparison with those patients who exhibited complete hydatidiform mole. There were no such d...Continue Reading

References

May 10, 1991·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P M StarkeyM C Rees
Apr 13, 1990·Science·S KovatsR DeMars
Aug 26, 1998·Developmental Immunology·J S HuntJ S Platt
Feb 23, 1999·Human Reproduction Update·H M Beier, K Beier-Hellwig
Mar 11, 2000·Human Reproduction Update·L A Salamonsen, L J Lathbury
Aug 24, 2001·American Journal of Obstetrics and Gynecology·D Goldman-WohlS Yagel
Oct 19, 2002·Journal of Reproductive Immunology·Lois A SalamonsenMelissa Brasted
Jun 27, 2003·Biology of Reproduction·Lucy Gardner, Ashley Moffett
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·In-Hak ChoiLieping Chen
Jan 8, 2004·Seminars in Cancer Biology·Vera RebmannHans Grosse-Wilde
Feb 6, 2004·Nature Immunology·Varuna R AluvihareAlexander G Betz
Aug 23, 2005·Gynecologic Oncology·Kenzo SonodaHitoo Nakano
Jan 21, 2006·Cancer Research·Claire E Lewis, Jeffrey W Pollard
Apr 6, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Munechika EnjojiMakoto Nakamuta
Apr 12, 2006·The Journal of Experimental Medicine·Ilona KryczekWeiping Zou
Apr 14, 2006·Chemotherapy·Jacek R Wilczyński
Jan 16, 2007·American Journal of Reproductive Immunology : AJRI·Rui ChenGil Mor
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lourdes ArruvitoLeonardo Fainboim
May 19, 2007·Fertility and Sterility·Audrone Eidukaite, Vytas Tamosiunas
Aug 11, 2007·Seminars in Cancer Biology·Vera RebmannHans Grosse-Wilde
Sep 11, 2007·Seminars in Cancer Biology·Vito PistoiaSoldano Ferrone
Sep 20, 2007·Gynecologic Oncology·Zoltan NagymanyokiRoss S Berkowitz
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Leisha A Emens
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Kenzo SonodaNorio Wake
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Jacek R WilczynskiMichal Radwan
Feb 26, 2008·Cancer Immunology, Immunotherapy : CII·Panagiotis TsagozisPavel Pisa
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charlie T GarnettJames W Hodge
Aug 22, 2008·Immunological Investigations·Stephen J Renaud, Charles H Graham
Jan 23, 2009·Cancer Investigation·Mahmoud R HusseinSaad Rezk Abdulwahed

❮ Previous
Next ❯

Citations

Apr 19, 2011·Medical Oncology·Ines Zidi, Nidhal Ben Amor
Jul 28, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ines Zidi, Nidhal Ben Amor
Nov 8, 2018·DNA and Cell Biology·Weimin HuangRu Feng
Nov 11, 2018·American Journal of Reproductive Immunology : AJRI·Małgorzata Walentowicz-SadleckaMagdalena Dutsch-Wicherek
Sep 18, 2020·Placenta·Orestis TsonisPanagiotis Kanavaros

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.