Abstract
In systemic sclerosis (SSC), certain abnormalities can occur in fibroblasts, endothelial cells, and immune system cells. Severe pathological changes such as visceral fibrosis and obliteration of the lumen of arteries may develop due to functional alterations of these cells. Because the vascular abnormality is a central mechanism of sclerosis, the aim of this study was to further investigate the impaired vascularity in the gingival tissues of SSC patients by means of immunohistochemistry using vascular endothelial growth factor A (VEGF-A), VEGF-C, and CD34 staining. Thirteen SSC patients and 11 systemically healthy controls who had moderate gingivitis were included in the study. Gingival biopsies were obtained from the interdental papilla, and VEGF-A, VEGF-C, and CD34 analyses were done by using immunohistochemical methods. Patients with scleroderma had higher levels of inflammatory infiltrate (P = .041) and microvessel density (P = .003) in their gingival biopsy samples. In contrast, when compared with the controls, the expressions of VEGF-A and VEGF-C were significantly lower in scleroderma patients (P = .033 and P = .015, respectively). These findings may reflect the defective vascularity and the pronounced histological infla...Continue Reading
References
Mar 1, 1992·The Journal of Pathology·R J PrescottP Fielding
Feb 1, 1988·Oral Surgery, Oral Medicine, and Oral Pathology·R E Wood, P Lee
Jun 1, 1984·Arthritis and Rheumatism·A D RoummG P Rodnan
Mar 1, 1984·Journal of Periodontology·L R EversoleC E Stone
Feb 1, 1994·Oral Surgery, Oral Medicine, and Oral Pathology·G NagyL Czirják
Oct 23, 1993·British Dental Journal·M Paley, P McLoughlin
Nov 10, 2000·European Journal of Haematology·F Dignat-George, J Sampol
Nov 25, 2000·Current Opinion in Rheumatology·A L Herrick
Nov 9, 2001·Journal of Periodontology·S M MirbodV K Pruthi
Sep 25, 2003·Clinical Rheumatology·Y T KonttinenI Virtanen
Jan 7, 2004·Annals of Internal Medicine·Sergio A Jimenez, Chris T Derk
Mar 18, 2004·Journal of Periodontology·Pelin GüneriHayal Boyacioğlu
Apr 13, 2004·Arthritis and Rheumatism·Nicoletta Del PapaAgostino Cortelezzi
Jun 5, 2004·Circulation Research·Oliver DistlerSteffen Gay
Aug 18, 2004·Lancet·Masataka KuwanaYasuo Ikeda
Sep 10, 2004·Clinical Oral Implants Research·P BullonM Battino
Aug 18, 2005·Clinical Science·Hiroyuki Takahashi, Masabumi Shibuya
Nov 9, 2005·Journal of Periodontology·G A ScardinaP Messina
Dec 16, 2005·Nature·Napoleone Ferrara, Robert S Kerbel
Mar 11, 2006·The Journal of Oral Implantology·Bartolomeo AssenzaAdriano Piattelli
Jul 27, 2006·Internal Medicine Journal·P J Roberts-Thomson, J G Walker
Citations
Apr 25, 2013·International Journal of Dental Hygiene·H K YuenR M Silver
Mar 1, 2016·Journal of Periodontology·Nicole PischonGabriela Riemekasten
May 20, 2016·Oral Diseases·S JungO Huck
Aug 6, 2011·Journal of Periodontology·W Keung LeungSam K S Ng
Sep 24, 2016·British Dental Journal·B J VealeJ D Pauling
Oct 11, 2017·Clinical Rheumatology·Gaetano IsolaGiovanni Matarese
Dec 27, 2018·Journal of Clinical Medicine·Roberta GualtierottiMassimo Cugno
Jan 29, 2010·Zeitschrift für Rheumatologie·J DetertF Buttgereit
Mar 5, 2020·Clinical Case Reports·Daniel N ReedLeigh E Yarborough
May 16, 2020·Mediators of Inflammation·Arleta WaszczykowskaPiotr Jurowski
Jun 19, 2014·Molecular Medicine Reports·Jiang-Chao LiXin-Yuan Guan
Jun 14, 2012·International Journal of Molecular Medicine·Giovanni MatareseGiuseppina Cutroneo