The Immunohistochemical Evaluation of Solid Pseudopapillary Tumors of the Pancreas and Pancreatic Neuroendocrine Tumors Reveals ERO1Lβ as a New Biomarker

Medicine
Junjie XieChenghong Peng

Abstract

Solid pseudopapillary tumor of the pancreas (SPTP) is a class of low-grade malignant tumors that carry a favorable prognosis after surgery. Our group has reported that dysfunctions in the endoplasmic reticulum (ER) protein processing pathway may play a role in tumor development. However, alterations of this pathway in other pancreatic tumors had not been well investigated. In this study, we collected 35 SPTP and pancreatic neuroendocrine tumor (PNET) specimens and described the clinicopathological features of them. We performed immunohistochemistry (IHC) for 6 representative proteins (ERO1Lβ, TRAM1, GRP94, BIP, P4HB, and PDIA4) involved in the ER pathway in both SPTP and PNET specimens. We compared the IHC scoring results of tumors and matched normal pancreas tissues and demonstrated that these proteins were downregulated in SPTP specimens. Five of these proteins (TRAM1, GRP94, BIP, P4HB, and PDIA4) did not display significant changes between PNET and normal pancreas tissue. However, ERO1Lβ was upregulated in PNET tissues compared to the normal tissues, which could be used as a pathological biomarker in the future.

References

May 7, 1992·Nature·P Walter
Mar 10, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·J Müller-HöckerA Sendelhofert
Jun 1, 2005·Journal of the American College of Surgeons·Theodossios Papavramidis, Spiros Papavramidis
Oct 26, 2006·Journal of Clinical Gastroenterology·Hyang-Eun SeoYoung-Kook Yoon
Feb 10, 2007·The FEBS Journal·Hiderou Yoshida
Mar 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Wendell W TangJingwu Xie
Sep 28, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Minhee ParkHoguen Kim
Jan 29, 2014·Molecular and Cellular Biology·Motoharu AwazawaKohjiro Ueki
Jun 6, 2014·Molecular Biology of the Cell·Devin DershYair Argon

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Citations

Oct 24, 2019·Cancer Biomarkers : Section a of Disease Markers·Zhenpeng ZhuJian Lin
Mar 3, 2017·World Journal of Surgery·Leon NaarNikolaos Arkadopoulos
Dec 4, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zeyu WangQuan Cheng
Jan 16, 2021·OncoTargets and Therapy·Haoyu LiJun Su

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Methods Mentioned

BETA
surgical resection
protein folding

Software Mentioned

Statistical Program for Social Sciences ( SPSS )

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