PMID: 6969038Sep 1, 1980Paper

The immunologic modulation of morbidity in schistosomiasis. Studies in athymic mice and in vitro granuloma formation

The American Journal of Tropical Medicine and Hygiene
S M PhillipsA G Bentley

Abstract

These studies were designated to test the hypothesis that granulomatous hypersensitivity associated with schistosomiasis, its modulation, and subsequent morbidity are contingent on thymic-dependent lymphocyte function. Studies in athymic mice were integrated with in vitro studies on granuloma formation. Athymic animals tolerate low levels of infection well but are increasingly susceptible to morbidity as the challenge burden increases or becomes associated with simultaneous additional stress such as bacterial infection. In addition, the athymic animals produce smaller granulomas and fail to demonstrate accelerated granuloma formation, the spontaneous modulation of granulomas, or significant resistance to reinfection. These deficiencies could be reversed by thymic reconstitution. In vitro studies indicate that the response to egg antigens was due to the interaction of two subpopulations of T lymphocytes. Studies of "in vitro granuloma formation" augmented the in vivo findings, suggesting that the "in vitro granuloma" represents an excellent analog for delayed hypersensitivities; granuloma production was contingent on a macrophage function and a specific subpopulation of T lymphocytes defined as Ly1+. Granuloma modulation was due...Continue Reading

Citations

Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J DoenhoffS Lucas
Nov 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A Dunn, R Kamel
May 13, 2004·Clinical and Diagnostic Laboratory Immunology·David Nascimento Silva-TeixeiraVirmondes Rodrigues
Jan 1, 1982·Journal of Immunological Methods·D G Colley, G L Freeman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.