The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection

Journal of Immunology Research
Ruilin YangHuichao Wang

Abstract

Hepatitis B can cause acute or chronic liver damage due to hepatitis B virus (HBV) infection. Cirrhosis or hepatocellular carcinoma (HCC) caused by chronic HBV infection often leads to increased mortality. However, the gut and liver have the same embryonic origin; therefore, a close relationship must exist in terms of anatomy and function, and the gut microbiota plays an important role in host metabolic and immune modulation. It is believed that structural changes in the gut microbiota, bacterial translocation, and the resulting immune injury may affect the occurrence and development of liver inflammation caused by chronic HBV infection based on the in-depth cognition of the concept of the "gut-liver axis" and the progress in intestinal microecology. This review aims to summarize and discuss the immunologic role of the gut microbiota in chronic HBV infection.

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Citations

Jan 20, 2019·International Journal of Molecular Sciences·Ivana MilosevicAmedeo Amedei
Jul 20, 2019·Clinical & Translational Immunology·Jennifer A Juno, Emily M Eriksson
Sep 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Lara Labarta-BajoElina I Zúñiga
Nov 3, 2020·Virus Research·Faizan Ahmed Sadiq
Jul 9, 2021·Frontiers in Immunology·Shuqin GuYongyin Li

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Methods Mentioned

BETA
biopsy

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