The immunological activity of Lycium barbarum polysaccharides liposome in vitro and adjuvanticity against PCV2 in vivo

International Journal of Biological Macromolecules
Ruonan BoDeyun Wang

Abstract

In previous researches, the results showed that Lycium barbarum polysaccharides (LBP) encapsulated with liposome could enhance the immune activity of LBP. Therefore, the present study was designed to investigate the effects of LBPL on spleen lymphocytes and macrophages of mice in vitro and evaluate the immunological adjuvant activity of PCV2 vaccine in vivo. The results showed that LBPL could significantly promote splenocyte proliferation synergistically with PHA or LPS, increase the ratio of CD4(+) to CD8(+) T cells and promote the cytokine secretion of macrophages; enhance PCV2-specific IgG antibody responses, promote Th1 cytokines (IFN-γ and TNF-a) and Th2 cytokine (IL-4) secretion. The histomorphological observation of spleen demonstrated that LBPL as a vaccine adjuvant also has good improvement and stimulating effect on the immune organ.

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Citations

Dec 17, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yun ChenJiaguo Liu
Jan 19, 2018·Aging and Disease·Yanjie GaoZhigang Chen
Oct 5, 2019·Oxidative Medicine and Cellular Longevity·Zhaokang ZhangYa Jia
Mar 21, 2019·Animal Models and Experimental Medicine·Ting OuyangLin-Zhu Ren
Dec 2, 2020·Helicobacter·Jo-Lewis Banga NdzouboukouXionglin Fan
Dec 15, 2020·International Journal of Biological Macromolecules·Yee HuangGuolian Bao
Oct 30, 2020·International Journal of Biological Macromolecules·Yu ZhengXiaofang Li
Jun 27, 2021·Pharmacology & Therapeutics·Zhiyong XiaoYongxiang Zhang

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