PMID: 2100106Nov 1, 1990Paper

The immunological implications of breast cancer: the physiopathological aspects and possible therapeutic strategies in our experience

Annali italiani di chirurgia
M Trerè, M Ciliberti

Abstract

The authors, after a short review on the physiopathological patterns which regulate the function of the immunological system in patients with neoplastic disease, report their clinical prospect study, performed on a population of 71 patients affected by breast cancer. The study has the aim to demonstrate the advantage of a complete immunological monitoring, and the efficacy of a prophylactic and therapeutic treatment with thymic hormones. Results of the study can be summarized as follow: 1) very low rate of septic complications. 2) Better results as to blood cells impairement in the group submitted to both chemo- and immunotherapy. 3) In the same group, the performance status (Karnofsky index) remained above 80% in most of cases. It is underlined in this study, the hypothesis of the prognostic value pertaining to the indexes of functionality of the immune system. Authors have indeed pointed out that early metastatic spread has been observed in the two patients, treated in 1st stage with surgery and immunotherapy, but not responding with improvement of biological data. This topic has to be developed in further studies, with the aim of changing and increasing the criteria for the staging of tumors, as the authors suggest.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences
T HattoriJ Yoshida
Anales españoles de pediatría
M E Cela De JuliánM A Cantalejo López
© 2021 Meta ULC. All rights reserved