Jun 1, 1976

The immunological properties of haptens coupled to thymus-independent carrier molecules. IV. The IgG response to dinitrophenylated Ficoll

European Journal of Immunology
G G KlausA M Cross


Dinitrophenylated polysucrose (DNP-Ficoll) elicits T cell-independent IgM anti-DNP antibody formation in mice. This antigen also elicits a heterogeneous IgG1 and IgG2 anti-DNP response, which is operationally as T-independent as the IgM response. However, a concomitant graft-versus-host reaction markedly enhances the IgG response (allogeneic effect). These results confirm those of others, indicating that a certain proportion of the precursors of IgG-producing cells can be triggered by some T-independent antigens. However, our results suggest that even with such antigens optimal triggering of IgG precursors requires T cell help.

Mentioned in this Paper

Neoplasm of Uncertain or Unknown Behavior of Thymus
Immunoglobulin Allotypes
Disease of Thymus Gland
Graft Vs Host Reaction
Thymic Tissue

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