The immunomodulatory effects of interferon-gamma on mature B-lymphocyte responses

Experientia
A JuradoG D Wetzel

Abstract

Interferon-gamma (IFN-gamma) exerts a broad spectrum of activities which affect the responses of mature B-cells. It strongly inhibits B-cell activation, acts as a B-cell growth factor (BCGF), and also induces final differentiation to immunoglobulin (Ig) production. IFN-gamma is deeply involved in the differential control of isotype expression, as it enhances IgG2a production and suppresses both IgG1 and IgE production. Although it is now possible to draw a general scheme of the effects of IFN-gamma on B-cells, a number of paradoxical results still exist in the field. In this manuscript, different experimental systems are analyzed in an attempt to explain these apparent paradoxes.

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Citations

May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sara A PaveglioMatthew E Poynter
Sep 8, 2016·Infection and Immunity·Elizabeth K NaglakRichard P Morrison
Apr 18, 2018·Cold Spring Harbor Perspectives in Biology·Elise AlspachRobert D Schreiber
Jun 22, 2018·Clinical Science·Amrita Bhattacharjee, Timothy W Hand
Sep 9, 2018·Clinical and Experimental Immunology·C Álvarez-LarrottaE Arango
Jul 3, 2021·International Journal of Molecular Sciences·Ewa FucBarbara Wróblewska
Jun 10, 2019·ACS Biomaterials Science & Engineering·David A Castilla-CasadiegoJorge Almodovar

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