The immunomodulatory effects of measles-mumps-rubella vaccination on persistence of heterologous vaccine responses

Immunology and Cell Biology
Petra ZimmermannNigel Curtis

Abstract

It is proposed that measles-containing vaccines have immunomodulatory effects which include a reduction in all-cause childhood mortality. The antibody response to heterologous vaccines provides a means to explore these immunomodulatory effects. This is the first study to investigate the influence of measles-mumps-rubella (MMR) vaccine on the persistence of antibodies to a broad range of heterologous infant vaccinations given in the first year of life. In total, 319 children were included in the study. All infants received routine vaccinations at 6 weeks, 4 and 6 months of age. At 12 months of age, 212 children were vaccinated with MMR and Haemophilus influenzae type b-meningococcus C (Hib-MenC) vaccines while the remaining 99 children had not yet received these vaccines. In the MMR/Hib-MenC-vaccinated group, blood was taken 28 ± 14 days after receiving these vaccines. Antibodies against diphtheria, tetanus, pertussis [pertussis toxin (PT), filamentous hemagglutinin, pertactin], poliomyelitis (type 1, 2, 3) and 13 pneumococcal serotypes were measured. Seroprotection rates and geometric mean antibody concentrations were compared between MMR/MenC-Hib-vaccinated and MMR/MenC-Hib-naïve participants. In the final analysis, 311 childr...Continue Reading

References

Dec 1, 1988·American Journal of Epidemiology·J D ClemensB Wojtyniak
Jun 1, 1996·The Journal of Infectious Diseases·G D HusseyD E Griffin
Jan 1, 1997·Vaccine·H F PabstM P Krezolek
Aug 26, 1998·JAMA : the Journal of the American Medical Association·H A GansY Maldonado
Aug 31, 2001·The Journal of Infectious Diseases·H GansA M Arvin
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin O C OtaArnaud Marchant
Aug 19, 2003·Vaccine·Inna G OvsyannikovaGregory A Poland
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie M CurtsingerMatthew F Mescher
Jul 10, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Anà HenninoBranka Horvat
May 14, 2010·Clinical and Vaccine Immunology : CVI·Stanley A Plotkin
Jun 7, 2011·Vaccine·Juliana Romualdo Nascimento SilvaUNKNOWN Collaborative Group for the Study of Yellow Fever Vaccines
Sep 7, 2012·PLoS Pathogens·Rory D de VriesRik L de Swart
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Johanneke KleinnijenhuisMihai G Netea
Nov 7, 2013·Journal of Innate Immunity·Johanneke KleinnijenhuisMihai G Netea
May 8, 2014·Advanced Biomedical Research·Abbas ZamanianGhazaleh Ahmadi Jazi
Jul 30, 2014·International Journal of Dermatology·Ahmad NofalHager Nofal
Jan 13, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Peter AabyChristine S Benn
Jan 13, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Johanneke KleinnijenhuisMihai G Netea
Nov 26, 2015·Trends in Molecular Medicine·Iana H HaralambievaGregory A Poland
May 10, 2016·Nature Reviews. Immunology·Helen S GoodridgeChristopher B Wilson
Jun 18, 2016·Vaccine·Mitra Saadatian-ElahiWilliam Warren
Oct 16, 2016·BMJ : British Medical Journal·Rama KandasamyAndrew J Pollard
Oct 16, 2016·BMJ : British Medical Journal·Julian P T HigginsArthur L Reingold
May 16, 2017·Archives of Disease in Childhood·Andrew J PollardNigel Curtis
Dec 20, 2017·Viral Immunology·Diane E Griffin
Feb 8, 2018·The Journal of Infectious Diseases·Bridget FreyneNigel Curtis
Jun 9, 2018·Expert Review of Vaccines·Petra Zimmermann, Nigel Curtis
Aug 9, 2018·BMC Public Health·Jesper Sloth HansenAne Bærent Fisker

❮ Previous
Next ❯

Citations

Jan 23, 2021·Biomedicines·Claudia FerlitoRaffaele D'Amelio
Apr 20, 2021·Frontiers in Immunology·Petra ZimmermannNigel Curtis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.