The immunopathogenesis of chronic and relapsing autoimmune uveitis - Lessons from experimental rat models

Progress in Retinal and Eye Research
Maria Diedrichs-MöhringGerhild Wildner

Abstract

Autoimmune diseases usually follow a relapsing-remitting or a chronic progressive course. To understand the underlying immunopathogenesis we investigated experimental Lewis rat models displaying both disease types, which were only dependent on the autoantigen peptide used for immunization. Retinal S-Antigen-peptide PDSAg induces chronic, monophasic disease, whilst interphotoreceptor retinoid-binding protein (IRBP)-peptide R14 causes a spontaneously relapsing-remitting course. R14-mediated uveitis can be re-induced by immunization; PDSAg-induced disease is even preventable by prior CFA-injection. T cells with different antigen specificities preferentially infiltrate the eyes from different sites, e.g. choroid or retinal vessels, they remain in the retina after resolution of inflammation for many weeks. The major inflammatory cell populations in the eyes during rat uveitis are CD4+ or CD8+ monocytes/macrophages. Chemokine mutants only suppress PDSAg-mediated EAU, while IFN-α-treatment ameliorated R14-, but worsened PDSAg-induced disease. Comparison of T cells revealed upregulated expression of 26 genes related to various signal transduction pathways upstream and downstream of IFN-γ only in T cells causing relapsing EAU. Intraocul...Continue Reading

Citations

May 15, 2020·Ocular Immunology and Inflammation·Soumyava BasuPaul Elkington
Nov 16, 2019·Scientific Reports·Fauziyya MuhammadDarren J Lee
Jul 29, 2020·Frontiers in Immunology·Atsunobu TakedaKoh-Hei Sonoda
Oct 9, 2019·Seminars in Immunopathology·Gerhild Wildner, Maria Diedrichs-Möhring
Sep 11, 2019·Progress in Retinal and Eye Research·Yusuke MurakamiKoh-Hei Sonoda
Nov 12, 2020·Journal of Clinical Medicine·Mathilde LeclercqDavid Saadoun
Mar 30, 2021·Progress in Retinal and Eye Research·Joo Youn Oh, Ryang Hwa Lee
Apr 6, 2021·Journal of Immunology Research·Kailei Guo, Xiaomin Zhang
Jul 6, 2021·Frontiers in Immunology·Lydia J BradleyLindsay B Nicholson
Jul 16, 2021·Expert Review of Clinical Immunology·Sara TouhamiBahram Bodaghi

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