PMID: 9163878May 1, 1997Paper

The immunophenotypic characterization of bovine lymphomas

Veterinary Pathology
W VernauJ L Heeney

Abstract

A prospective analysis of 38 cases of bovine lymphoma was performed. Thirty-five of the lymphomas were considered enzootic because of serologic or molecular biologic association with the bovine leukemia virus (BLV). The three remaining cases were in cattle < 1 year of age and were not associated with BLV and hence were considered sporadic lymphomas. Utilizing the national cancer Institute Working Formulation for the morphologic classification of human non-Hodgkin's lymphoma, 54.3% (19/35) of the enzootic lymphomas were classified as the diffuse large cleaved cell type. The cells of the 35 enzootic lymphomas expressed a consistent immunophenotype represented by MHCII+, gamma-heavy chain+, and lambda-light chain+; this constellation of markers indicated a mature B-cell phenotype. The three sporadic lymphomas failed to express MHCII antigen despite the presence of other B-cell antigens. There was no correlation between morphologic cell type and immunophenotype in these bovine lymphomas.

References

Jan 1, 1978·Clinical Immunology and Immunopathology·B G van CampJ Radl
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N SagataY Ikawa
Oct 1, 1988·Histopathology·P Van der Valk, C J Meijer
Dec 3, 1987·The New England Journal of Medicine·M D Cooper
Jul 1, 1984·British Journal of Haematology·B G Durie
Feb 1, 1994·Leukemia Research·M W SchnurrR M Jacobs
Nov 4, 1963·Annals of the New York Academy of Sciences·P J BRANDLY, G MIGAKI

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Citations

Nov 10, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·T D VoE Gruys
Aug 31, 2004·Veterinary Clinical Pathology·Sam J HarboWilliam C Davis
May 24, 2000·The Journal of Veterinary Medical Science·T TakahashiK Kadota
Jun 6, 2009·The Journal of Veterinary Medical Science·Hidetsugu HondaKoichi Kadota
May 22, 2004·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Eva A SartinEllen B Belknap
Nov 14, 2006·Veterinary Pathology·J MeyerD Bienzle
Mar 12, 2003·Veterinary Pathology·B A Valentine, S P McDonough
Sep 21, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·J BeyerM Ziller
Sep 19, 2006·Nature Reviews. Microbiology·Adriano Aguzzi, Mathias Heikenwalder
Oct 1, 2009·Physiological Reviews·Adriano Aguzzi, Anna Maria Calella
Apr 26, 2021·Journal of Comparative Pathology·Joana Gp JacintoCinzia Benazzi
Jan 22, 2005·Science·Mathias HeikenwalderAdriano Aguzzi

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