The immunosuppressant FK506 inhibits the damage to mouse pancreatic islets induced by low dose streptozocin

Cell and Tissue Research
G PapaccioG Chieffi Baccari

Abstract

Diabetes mellitus was induced in 40 male C57BL6 mice by injection of a low dose of streptozocin (45 mg/kg body weight) on 5 consecutive days. Twenty four of the mice were immunosuppressed by administration of 1.5 mg FK506/kg body weight daily for 10, 15, 18 and 24 days. Administration of FK506 almost completely inhibited the streptozocin-induced islet damage, and consequently glycaemia remained normal. In FK506-treated animals any inflammatory infiltrate was very sparse and was limited to the vascular pole of the islets. Immunocytochemical results demonstrated that infiltrating cells were Ia-immunoreactive, but were not activated. Ultrastructural observations confirmed the absence of B cell necrosis and degranulation in FK506-treated mice; the few infiltrating elements encountered did not contain phagocytic vesicles or show other signs of activation.

References

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May 1, 1992·Histochemistry·G Papaccio, G Chieffi-Baccari
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Jan 1, 1986·Transplantation·H J HahnR Warzock
Jan 1, 1993·Acta Anatomica·G PapaccioV Mezzogiorno

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Citations

Apr 25, 2006·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Bogusław MachalińskiElzbieta Dabkowska
Oct 24, 2014·EMBO Molecular Medicine·Daniel BilbaoNadia Rosenthal
Jul 17, 2001·Journal of Cellular Biochemistry. Supplement·G PapaccioM Pedullà

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