PMID: 26838245Feb 4, 2016Paper

The Immunotyping Distribution of Serum Monoclonal Paraprotein and Environmental Impact on Multiple Myeloma (MM) and Monoclonal Gammopathy of Uncertain Significance (MGUS) in Taiwan: A Medical Center-Based Experience

Asian Pacific Journal of Cancer Prevention : APJCP
Chih-Chun ChangFang-Yeh Chu

Abstract

Whether ambient exposure to environmental pollutants leads to hematopoietic malignancies such as multiple myeloma (MM) remains to be ascertained. Therefore, we aimed to investigate the immunotyping distribution of serum monoclonal paraprotein and the environmental influence on MM and monoclonal gammopathy of uncertain significance (MGUS) in the Taiwanese population. Serum protein electrophoresis with immunosubtraction by the capillary zone electrophoresis method was performed as primary screening for MM and MGUS. Clinical, pathological, and residence data of patients were also obtained. From August, 2013 to June, 2015, a total of 327 patients underwent serum protein electrophoresis with immunosubtraction. Among these, 281 demonstrated no remarkable findings or non-malignant oligoclonal gammopathy, 23 were detected to have MGUS, 18 were identified as MM, and a further 5 were found as other malignancies. The most frequent immunotyping distribution of serum monoclonal paraprotein was IgG kappa (54.3%, n=25), followed by IgA lambda (15.2%, n=7) and IgG lambda (10.9%, n=5) in subjects with gammopathy. Additionally, it was shown that the elderly (OR: 4.61, 95% CI: 1.88-11.30, P<0.01) and males (OR: 2.04, 95% CI: 1.04-4.02, P=0.04) ha...Continue Reading

References

Jan 17, 2003·Mayo Clinic Proceedings·Robert A KylePhilip R Greipp
Oct 11, 2003·Stroke; a Journal of Cerebral Circulation·Shang-Shyue TsaiChun-Yuh Yang
Oct 28, 2003·Clinical Chemistry·Cécile Gay-BellileThierry Le Bricon
Dec 13, 2006·Toxicology Letters·Mathuros RuchirawatHerman Autrup
Feb 3, 2007·The New England Journal of Medicine·Kristin A MillerJoel D Kaufman
Jun 22, 2007·The New England Journal of Medicine·Robert A KyleS Vincent Rajkumar
Jul 20, 2007·American Journal of Clinical Pathology·Zhaohai YangRobert W Hardy
Jul 30, 2011·Journal of Toxicology and Environmental Health. Part a·Hui-Fen ChiuChun-Yuh Yang
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Niloofar RajabliGholamreza Roshandel
Nov 7, 2013·International Journal of Environmental Research and Public Health·Khalid Al-Ahmadi, Ali Al-Zahrani
Dec 3, 2014·The Lancet Oncology·S Vincent RajkumarJesus F San Miguel
Dec 17, 2014·Annals of Global Health·Dana Hashim, Paolo Boffetta
Apr 30, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Chih-Chun ChangJiann-Ming Wu
May 7, 2015·International Journal of Cancer. Journal International Du Cancer·Martha S LinetUNKNOWN Chinese Center for Disease Control and Prevention-U.S. National Cancer Institute Benzene Study Group
May 9, 2015·The Science of the Total Environment·Nicholas WintersUNKNOWN Canadian Cancer Registries Epidemiology Group
Aug 15, 2015·Thoracic Cancer·Gongbo ChenXiaonong Zou
Sep 24, 2015·Scientific Reports·Hong-Li PanGuang-Biao Zhou
Oct 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Noorwati SutandyoLeovinna Widjaja

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.