The impact analysis of a multiplex PCR respiratory panel for hospitalized pediatric respiratory infections in Japan

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Taito KitanoSayaka Yoshida

Abstract

Rapid molecular diagnosis of infections has contributed to timely treatments and antimicrobial stewardship. However, the benefit and cost-effectiveness vary in each country or community because they have different standard practices and health care systems. In Japan, rapid antigen tests (RATs) have been frequently used for pediatric respiratory infections. We investigated the impact and cost-effectiveness of a multiplex PCR (mPCR) respiratory panel for pediatric respiratory infections in a Japanese community hospital. We replaced RATs with an mPCR respiratory panel (FilmArray®) for admitted pediatric respiratory infections on March 26, 2018. We compared the days of antimicrobial therapy (DOT) and length of stay (LOS) during the mPCR period (March 2018 to April 2019) with those of the RAT period (March 2012 to March 2018). During the RAT and mPCR periods, 1132 and 149 patients were analyzed. The DOT/case was 12.82 vs 8.56 (p < 0.001), and the LOS was 8.18 vs 6.83 days (p = 0.032) in the RAT and mPCR groups, respectively. The total costs during admissions were ∖258,824 ($2331.7) and ∖243,841 ($2196.8)/case, respectively. Pathogen detection rates were 30.2% vs 87.2% (p < 0.001). Compared to conventional RATs, the mPCR test contrib...Continue Reading

Citations

Jun 20, 2020·ACS Pharmacology & Translational Science·Zaneeta DhesiDavid M Livermore
Aug 20, 2021·JA Clinical Reports·Masaru ShimizuTomohiro Takeda
Nov 21, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jense WilsAnnette Schuermans
Jul 6, 2021·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kota YoshidaMuneyuki Takeuchi

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Methods Mentioned

BETA
PCR

Software Mentioned

StataCorp
Excel
Stata

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