The impact and potential etiology of teratospermia in the domestic cat and its wild relatives

Theriogenology
B S PukazhenthiD E Wildt

Abstract

Teratospermia (production of >60% morphologically abnormal sperm/ejaculate) is relatively common among various species in the family Felidae, which is comprised of 37 species. Over two decades of research in this area have produced a significant understanding of the phenotypic expression, its impacts on sperm function and etiology. There is good evidence suggesting that a reduction in genetic diversity contributes to this phenomenon. Results to date demonstrate that spermatozoa from teratospermic donors are compromised in the ability to undergo capacitation and the acrosome reaction, penetrate the zona-pellucida, fertilize conspecific oocytes and survive cryopreservation. Recent studies also reveal abnormalities in chromatin integrity in sperm from teratospermic donors, which, interestingly, fails to impact fertilization or embryo development after intracytoplasmic sperm injection. Through planned inbreeding studies, we now have established that teratospermic cats also produce more spermatozoa by virtue of more sperm producing tissue, more germ cells per Sertoli cell and reduced germ cell loss during spermatogenesis. Overall, it now is clear that gain in sperm quantity is achieved at the expense of sperm quality, suggesting an ...Continue Reading

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Citations

Jul 9, 2014·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Imke LuedersMartin Dehnhard
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