The impact of 2-dose routine measles, mumps, rubella, and varicella vaccination in France on the epidemiology of varicella and zoster using a dynamic model with an empirical contact matrix

Clinical Therapeutics
Mario J N M OuwensSophie Alain

Abstract

Varicella has a high incidence affecting the vast majority of the population in France and can lead to severe complications. Almost every individual infected by varicella becomes susceptible to herpes zoster later in life due to reactivation of the latent virus. Zoster is characterized by pain that can be long-lasting in some cases and has no satisfactory treatment. Routine varicella vaccination can prevent varicella. The vaccination strategy of replacing both doses of measles, mumps, and rubella (MMR) with a combined MMR and varicella (MMRV) vaccine is a means of reaching high vaccination coverage for varicella immunization. The objective of this analysis was to assess the impact of routine varicella vaccination, with MMRV in place of MMR, on the incidence of varicella and zoster diseases in France and to assess the impact of exogenous boosting of zoster incidence, age shift in varicella cases, and other possible indirect effects. A dynamic transmission population-based model was developed using epidemiological data for France to determine the force of infection, as well as an empirically derived contact matrix to reduce assumptions underlying these key drivers of dynamic models. Scenario analyses tested assumptions regarding ...Continue Reading

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Citations

Oct 26, 2018·Expert Review of Vaccines·Sandra E TalbirdLara J Wolfson
Nov 9, 2018·The Pediatric Infectious Disease Journal·Vana SpoulouTimo Vesikari
Oct 1, 2019·Human Vaccines & Immunotherapeutics·Jonathan GrahamVincent J Daniels
Jul 2, 2020·ClinicoEconomics and Outcomes Research : CEOR·C AzzariL J Wolfson

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