The Impact of a Single Dose of a Polyphenol-Rich Seaweed Extract on Postprandial Glycaemic Control in Healthy Adults: A Randomised Cross-Over Trial

Nutrients
Margaret MurrayMaxine P Bonham

Abstract

This study investigated the impact of a polyphenol-rich seaweed extract on postprandial glycaemia in healthy adults, and, as a secondary outcome, the influence of ethnicity on these outcomes. Thirty-eight volunteers (26 non-Asian, 12 Asian) aged 19 to 56 years participated in this double-blind, placebo-controlled, randomised cross-over trial. Participants each consumed a low (500 mg), and high (2000 mg) dose of the polyphenol-rich brown seaweed (Fucus vesiculosus) extract, as well as a cellulose placebo (2000 mg), 30 min prior to 50 g of available carbohydrate from white bread. Postprandial blood glucose and plasma insulin concentrations were measured over two hours (fasting, 15, 30, 45, 60, 90, and 120 min) from a finger prick blood sample. Data were analysed using a repeated measures analysis of variance. Compared with the placebo, neither dose had a lowering effect on postprandial glucose or insulin responses. However, individuals of an Asian background experienced consistently elevated plasma insulin responses, assessed using an incremental area under the curve, compared with non-Asian participants, irrespective of supplement (p= 0.016). These results suggest an increased risk of insulin resistance among Asian populations, ...Continue Reading

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Citations

Aug 1, 2018·Marine Drugs·Manuel Gómez-GuzmánJulio Gálvez
Mar 7, 2019·Nutrition Reviews·Paul CherryPhilip J Allsopp
Sep 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela Gabbia, Sara De Martin
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Jul 30, 2020·Marine Drugs·João CotasLeonel Pereira
Oct 4, 2020·Marine Drugs·Raquel MateosHerminia Domínguez
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Enver KeleszadeAdele Costabile

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Methods Mentioned

BETA
ELISA

Software Mentioned

FoodWorks
Statistical Package for Social Sciences ( SPSS )
- Explorer
Phenol

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