The impact of a two-compound product containing calcipotriol and betamethasone dipropionate (Daivobet/ Dovobet) on the quality of life in patients with psoriasis vulgaris: a randomized controlled trial

The British Journal of Dermatology
P C Van de Kerkhof

Abstract

Psoriasis is a common disease and may have a significant impact on patients' quality of life (QoL). To assess the impact on QoL of a new two-compound product (TCP) (Daivobet/Dovobet; LEO Pharma) which combines the topical vitamin D analogue calcipotriol (50 microg g(-1)) and the World Health Organization group III corticosteroid betamethasone dipropionate (0.5 mg g(-1)) in a single ointment vs. calcipotriol monotherapy using a placebo-controlled study design. The Psoriasis Disability Index and the EuroQoL 5D questionnaire and visual analogue scale (VAS) were used in this study, which enrolled 828 patients with psoriasis vulgaris for treatment lasting up to 4 weeks. These QoL instruments were completed by patients before and after treatment with the TCP of calcipotriol and betamethasone dipropionate used once or twice daily, calcipotriol alone twice daily and vehicle twice daily. The TCP used once or twice daily and calcipotriol used twice daily were found to have statistically significant beneficial effects on patients' QoL over the course of treatment, and each was demonstrated to have a statistically significant benefit on QoL over vehicle. The TCP, applied once daily, was superior to calcipotriol twice daily in terms of redu...Continue Reading

References

Dec 1, 1990·The British Journal of Dermatology·A Y FinlayM S Salek
Jan 1, 1987·Clinical and Experimental Dermatology·A Y Finlay, S E Kelly
Apr 1, 1995·Headache·M L Essink-BotF F Rutten
Feb 1, 1995·The British Journal of Dermatology·A Y Finlay, E C Coles
May 1, 1994·Clinical and Experimental Dermatology·A Y Finlay, G K Khan
Aug 7, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·P C van de KerkhofM V Kuipers
May 3, 2000·The British Journal of Dermatology·B KirbyC E Griffiths
Oct 14, 2000·Journal of the European Academy of Dermatology and Venereology : JEADV·T F PoynerZ V Williams
Nov 14, 2001·American Journal of Clinical Dermatology·L J ScottK L Goa

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Citations

Nov 23, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Laurence Le CleachOlivier Chosidow
Oct 5, 2011·American Journal of Clinical Dermatology·Paul L McCormack
May 17, 2014·Applied Research in Quality of Life·Beata Szramka-PawlakRyszard Zaba
Oct 6, 2007·The Journal of Dermatological Treatment·Hanan MorsyGregor B E Jemec
Oct 14, 2009·The Journal of Dermatological Treatment·Rajesh BalkrishnanSteven R Feldman
Jun 17, 2009·Expert Review of Pharmacoeconomics & Outcomes Research·Mohammad K A Basra, Muhammad Shahrukh
Mar 24, 2006·Expert Opinion on Pharmacotherapy·A CharakidaA C Chu
Aug 12, 2009·Expert Opinion on Pharmacotherapy·Rosita SaracenoSergio Chimenti
Apr 1, 2006·The Journal of Investigative Dermatology·Jane UnaezeRobert S Stern
Feb 24, 2005·Clinical and Experimental Dermatology·P C M van de Kerkhof
May 21, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·J P OrtonneS Segaert
Nov 26, 2005·The British Journal of Dermatology·P C M van de Kerkhof
Dec 18, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·P C M van de KerkhofK Papp
Mar 22, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·G Schmid-OttA Götz
May 26, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·S DevauxC Paul
Nov 2, 2014·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Yaling YangLouise Longworth
Jun 22, 2005·Journal of the American Academy of Dermatology·David A Norris
May 22, 2010·Journal of Cutaneous Medicine and Surgery·Kim A Papp, Wayne Carey
Dec 24, 2009·Public Understanding of Science·Eefje CuppenCees Midden
May 1, 2011·Science, Technology & Human Values·Arthur C PetersenJeroen P van der Sluijs
May 10, 2018·The Journal of Dermatology·Shinichi ImafukuHae Jun Song
Apr 2, 2013·The Cochrane Database of Systematic Reviews·Anne R MasonHelen Hancock
Sep 8, 2016·The Journal of Dermatology·Saori MasakiShinichi Imafuku
Jun 8, 2006·Health and Quality of Life Outcomes·Monali J BhosleRajesh Balkrishnan

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