The impact of acute aerobic exercise on chitinase 3-like protein 1 and intelectin-1 expression in obesity

Experimental Biology and Medicine
Chun-Jung HuangYoshimi Shibata

Abstract

Chitinase 3-like 1 (CHI3L1) and intelectin 1 (ITLN-1) recognize microbial N-acetylglucosamine polymer and galactofuranosyl carbohydrates, respectively. Both lectins are highly abundant in plasma and seem to play pro- and anti-inflammatory roles, respectively, in obesity and inflammatory-related illnesses. The aim of this study was to examine whether plasma levels of these lectins in obese subjects are useful for monitoring inflammatory conditions immediately influenced by acute aerobic exercise. Plasma interleukin-6, a pro-inflammatory cytokine, was also examined. Twenty-two (11 obese and 11 normal-weight) healthy subjects, ages 18-30 years, were recruited to perform a 30 min bout of acute aerobic exercise at 75% VO2max. We confirmed higher baseline levels of plasma CHI3L1, but lower ITLN-1, in obese subjects than in normal-weight subjects. The baseline levels of CHI3L1 were negatively correlated with cardiorespiratory fitness (relative VO2max). However, when controlled for BMI, the relationship between baseline level of CHI3L1 and relative VO2max was no longer observed. While acute aerobic exercise elicited an elevation in these parameters, we found a lower ITLN-1 response in obese subjects compared to normal-weight subjects. ...Continue Reading

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Citations

Sep 23, 2016·Journal of the Neurological Sciences·C SanfilippoM Di Rosa
Jan 23, 2019·Frontiers in Physiology·Cynthia Aparecida de CastroAna Cláudia Garcia de Oliveira Duarte

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Methods Mentioned

BETA
hormone replacement therapy
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Statistical Package for the Social Sciences ( SPSS

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