The impact of acute atrial fibrillation on the prothrombotic state in patients with essential hypertension

Clinical Biochemistry
Jianping HouMingfang Huang

Abstract

To investigate whether acute atrial fibrillation (AF) creates a prothrombotic state in hypertensive patients, and to assess the evolution in research indices after cardioversion. Plasma levels of von Willebrand factor (vWf), soluble P-selectin and fibrin D-dimers were measured in hypertensive patients with acute AF pre-cardioversion and at 1, 7, 14, and 30days post-cardioversion. The results were compared with hypertensive controls and healthy controls. Pre-cardioversion plasma vWf levels in acute AF patients were similar to those of controls; however, post-cardioversion, the vWf levels increased significantly and only returned to baseline levels 14days later. Compared with controls, acute AF patients had higher levels of fibrin D-dimers, which lasted at least 14days after cardioversion. This study demonstrated that hypertensive patients with acute AF have an abnormal prothrombotic state, which persists for up to 14days after cardioversion.

References

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Citations

Dec 23, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Nathan E K ProcterJohn D Horowitz
Nov 5, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Omer AkyolChu-Huang Chen
Sep 28, 2017·European Journal of Haematology·Waldemar E WysokinskiRobert D McBane
Aug 20, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Naser AmmashWaldemar E Wysokinski
Mar 18, 2017·Medical Science Monitor Basic Research·Alexander WeymannIntegrated Meta-Analysis Of Cardiac Surgery And Cardiology-Group Imcsc-Group

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