PMID: 11921496Mar 30, 2002Paper

The impact of acute dynamic exercise on intraocular pressure: role of the beta 2-adrenergic receptor polymorphism

The Journal of International Medical Research
K GüngörA Sükrü Aynacioglu

Abstract

Effects of mutations in the beta 2-adrenergic receptor (beta 2AR) gene on intraocular pressure (IOP), in response to acute dynamic exercise, were investigated in 19 healthy males (age 22.6 +/- 2.8 years). Intraocular pressures were measured pre- and post-exercise. Weight, height, body mass index, and maximal oxygen (VO2max) uptake were recorded and subjects were genotyped for Arg16Gly, Gln27Glu and Thr164Ile mutations of the beta 2AR gene. Post-exercise, reductions in mean IOP values were found in 16 subjects with the Gly16Gly and Arg16Gly genotypes, but these values remained low in the eight patients with the Gly16Gly genotype 3 h post-exercise, whereas they returned to baseline within 1 h in the eight subjects with the Arg16Gly genotype. beta 2AR stimulation during exercise could be an important regulator of IOP response and determining beta 2AR polymorphisms may improve understanding of pathogenesis and treatment selection in ophthalmic diseases, e.g. glaucoma.

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Citations

Aug 15, 2009·BMC Ophthalmology·Konstantinos NatsisVasilios Karabatakis
Apr 16, 2014·Omics : a Journal of Integrative Biology·Kıvanç GüngörŞükrü Aynacıoğlu
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