PMID: 9438514Jan 23, 1998Paper

The impact of acute ethanol on reproductive hormone synthesis, processing, and secretion in female rats at proestrous

Alcoholism, Clinical and Experimental Research
N LaPagliaN V Emanuele

Abstract

It is the purpose of this study to investigate the effects of acute ethanol (EtOH) on the female rat hypothalamic-pituitary-gonadal (HPG) axis. The molecular and cellular mechanistic details of such effects have been studied intensively in the male rat. However, there has been relatively little in-depth study of EtOH's effects on the adult, postpubertal female rat. Adult female rats with confirmed 4- or 5-day estrous cycles were given a single injection of EtOH or saline between noon and 1:00 PM on proestrous and were killed at 4:00 PM. EtOH caused a sharp 97% reduction in luteinizing hormone (LH) serum levels (p < 0.001), compared with controls with no concomitant change in LH mRNA. EtOH also significantly reduced hypothalamic LH releasing hormone (LHRH) by 49% (p < 0.01), with no change in content of the precursor pro-LHRH compared with saline-injected controls. The ratio of LHRH to pro-LHRH was also significantly reduced by EtOH (p < 0.05), compared with control. There was no EtOH-induced change in LHRH mRNA. Compared with saline, EtOH reduced both serum estradiol by 37% (p < 0.02) and progesterone by 47% (p < 0.001). These results show that EtOH has profound disruptive effects on the female HPG axis. Our data suggests that ...Continue Reading

References

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Jan 1, 1990·Neuroendocrinology·W L Dees, C W Skelley
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Citations

Sep 27, 2012·Occupational Medicine·C-C LinP-C Chen
Apr 5, 2013·International Journal of Environmental Research and Public Health·Ching-Chun LinPau-Chung Chen
Nov 30, 2013·Human Reproduction·J LyngsøC H Ramlau-Hansen
Aug 26, 2006·Alcoholism, Clinical and Experimental Research·Melissa HermanCatherine Rivier
Nov 26, 2014·Alcoholism, Clinical and Experimental Research·Joanna H SliwowskaJoanne Weinberg
May 14, 2014·Alcoholism, Clinical and Experimental Research·María-Esther CruzRoberto Domínguez
Jan 31, 2006·Alcoholism, Clinical and Experimental Research·Kristine M WirenDeborah A Finn

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