The impact of acute lung injury, ECMO and transfusion on oxidative stress and plasma selenium levels in an ovine model

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Charles I McDonaldJohn F Fraser

Abstract

The purpose of this study was to determine the effects of smoke induced acute lung injury (S-ALI), extracorporeal membrane oxygenation (ECMO) and transfusion on oxidative stress and plasma selenium levels. Forty ewes were divided into (i) healthy control (n=4), (ii) S-ALI control (n=7), (iii) ECMO control (n=7), (iv) S-ALI+ECMO (n=8) and (v) S-ALI+ECMO+packed red blood cell (PRBC) transfusion (n=14). Plasma thiobarbituric acid reactive substances (TBARS), selenium and glutathione peroxidase (GPx) activity were analysed at baseline, after smoke injury (or sham) and 0.25, 1, 2, 6, 7, 12 and 24h after initiation of ECMO. Peak TBARS levels were similar across all groups. Plasma selenium decreased by 54% in S-ALI sheep (1.36±0.20 to 0.63±0.27μmol/L, p<0.0001), and 72% in sheep with S-ALI+ECMO at 24h (1.36±0.20 to 0.38±0.19, p<0.0001). PRBC transfusion had no effect on TBARS, selenium levels or glutathione peroxidase activity in plasma. While ECMO independently increased TBARS in healthy sheep to levels which were similar to the S-ALI control, the addition of ECMO after S-ALI caused a negligible increase in TBARS. This suggests that the initial lung injury was the predominant feature in the TBARS response. In contrast, the addition o...Continue Reading

References

Apr 8, 1999·Intensive Care Medicine·P G MetnitzW Druml
Mar 1, 2000·British Medical Bulletin·J M Gutteridge, J Mitchell
Jan 30, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·S P WardleA M Weindling
Dec 12, 2002·Chest·John D LangSadis Matalon
May 20, 2003·Biological Chemistry·Yasuhide MiyamotoNaoyuki Taniguchi
Sep 23, 2003·American Journal of Respiratory Cell and Molecular Biology·Chung-Wai ChowGregory P Downey
Jan 26, 2005·Pediatric Pulmonology·Keith J CollardJanet E Holley
Oct 21, 2005·The New England Journal of Medicine·Gordon D RubenfeldLeonard D Hudson
Mar 18, 2006·Current Opinion in Critical Care·Michael GeogheganJeremy Powell-Tuck
Apr 22, 2006·Journal of Applied Physiology·Thomas RiedelAndreas Schibler
Dec 5, 2009·Critical Reviews in Clinical Laboratory Sciences·Daniela GiustariniRanieri Rossi
Nov 18, 2011·The New England Journal of Medicine·Daniel Brodie, Matthew Bacchetta
Mar 31, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Charles I McDonaldJohn F Fraser
Oct 17, 2012·Critical Care : the Official Journal of the Critical Care Forum·Kiran ShekarJohn F Fraser
Jul 31, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Charles McDonaldJohn F Fraser
Sep 3, 2013·Vox Sanguinis·G SimonovaY L Fung
Feb 1, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Charles Ian McDonaldYoke Lin Fung
Jun 3, 2014·Critical Care : the Official Journal of the Critical Care Forum·Simone Brasil de Oliveira IglesiasRoseli Oselka Saccardo Sarni

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Citations

Jun 19, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Esther Humann-Ziehank
Oct 17, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Bethany J FarrNilesh M Mehta

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