The impact of acute rejection in kidney transplantation on long-term allograft and patient outcome

Nephro-urology Monthly
Mojgan JalalzadehMohammad Hassan Ghadiani

Abstract

Patients with end stage renal disease (ESRD) can be sustained with dialysis therapy. In this study, we followed up the effect of early acute and late acute rejections on survival rates of patients' grafts. We investigated the timing and frequency of acute rejection episodes related to long-term patient-graft survival in Taleghani hospital between 1990 and 2011. Recipients were divided into three groups as Group-1 (no rejection), Group-2 (early acute rejection [EAR]: less than 3-months) and Group-3 (late acute rejection [LAR]: after 3 months of transplant). One and five-year patient's survival rates were 94.87% and 93.8%, and graft survival (GS) rates were 92.6% and 81.9%. EAR and LAR occurred in 125 (18.8%) and 77 (11.7%) patients, respectively. Graft and patient survival rates at one and five years were as follows; Group-1 (Graft 96.7% and 94.5% patient: 97.4% and 96.8%), Group-2 (Graft: 72% and 61%, patient: 85.6% and 84%), Group-3 (Graft: 84.4% and 36.8%, patient: 92.2% and 89.4%). Recipient age, type and length of dialysis, number of transplantations and the status of panel reactivity antibody (PRA) had no effect on the type of rejection. LAR was more commonly associated with males (P = 0.001) and donors' age was associated...Continue Reading

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Citations

Mar 25, 2016·World Journal of Transplantation·Gerold ThölkingStefan Reuter
Jul 22, 2017·The Cochrane Database of Systematic Reviews·Angela C WebsterSue J Carr
Sep 19, 2017·Clinical Transplantation·Mohamad M AlkadiThangamani Muthukumar
May 17, 2019·Contrast Media & Molecular Imaging·Ulrich JehnStefan Reuter
Mar 14, 2020·Scientific Reports·Alexandre JadoulFrançois Jouret
Feb 23, 2020·International Journal of Molecular Sciences·Shanshan ZhaoGuihua Hou
Sep 21, 2020·Transplantation Proceedings·Murat SevmisMurathan Uyar
Sep 5, 2019·Current Opinion in Organ Transplantation·Luciana Da Silveira CavalcanteShannon N Tessier

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

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