The impact of adenosine on the release of acetylcholine, dopamine, and norepinephrine from the cat carotid body

Neuroscience Letters
R S FitzgeraldIrene Chang

Abstract

Exogenously administered adenosine provokes an increase in respiration in both animal models and in man. Administered near the carotid body adenosine increases neural output from the carotid body in rats and cats. Hypoxia has the same effect. Hypoxia also provokes a release of acetylcholine (ACh), dopamine (DA), and norepinephrine (NE) from the carotid body. The present study aimed to determine the effect of exogenous adenosine on the release of ACh, DA, and NE from the carotid bodies of cats. After a recovery period (from surgery) carotid bodies were first incubated for 10 (DA, NE) or 15 (ACh) min in Eppendorf tubes containing 85 microL of a physiological salt solution equilibrated with 40% O2/5% CO2 at 37 degrees C (hyperoxia). At the end of the incubation period the medium was drawn off, and measured for ACh, DA, and NE using HPLC-ECD methods. Next 85 microL of the medium and the tubes were equilibrated with a hypoxic gas mixture (4% O2/5% CO2) and the carotid bodies were incubated for 10 (DA, NE) or 15 (ACh) min, at the end of which the medium was drawn off and measured for ACh, DA, and NE. In the ACh studies there followed a post-hypoxic hyperoxic exposure (40% O2/5% CO2). ACh tubes were then made 100 microM with respect t...Continue Reading

References

Aug 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·E C Monteiro, J A Ribeiro
Apr 1, 1988·Trends in Pharmacological Sciences·B B Fredholm, T V Dunwiddie
Jul 1, 1986·British Journal of Pharmacology·D S McQueen, J A Ribeiro
Feb 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·E C Monteiro, J A Ribeiro
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C LondosJ Wolff
Sep 1, 1981·British Journal of Pharmacology·D S McQueen, J A Ribeiro
Jan 1, 1993·Journal of Neurochemistry·S James, P J Richardson
Feb 1, 1996·Progress in Neurobiology·A M Sebastião, J A Ribeiro
Nov 5, 1999·Brain Research·R S FitzgeraldH Y Wang
Feb 1, 2002·Brain Research·Hay-Yan Jack Wang, Robert S Fitzgerald

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Citations

May 28, 2005·Respiratory Physiology & Neurobiology·Aida Bairam, John L Carroll
Jun 17, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J Koos
Jun 30, 2012·Respiratory Physiology & Neurobiology·E Stéphan-BlanchardK Chardon
Oct 13, 2009·Respiratory Physiology & Neurobiology·Lalah NianeAida Bairam
Feb 8, 2007·Respiratory Physiology & Neurobiology·Machiko ShirahataRobert S Fitzgerald
Feb 6, 2007·Respiratory Physiology & Neurobiology·P Zapata
Jan 31, 2006·British Journal of Pharmacology·Sílvia V Conde, Emília C Monteiro
Jan 27, 2006·American Journal of Physiology. Cell Physiology·Fenglian XuAmy Tse

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