Apr 18, 2020

Stress reactivity elicits a tissue-specific reduction in telomere length in ageing zebrafish (Danio rerio)

BioRxiv : the Preprint Server for Biology
J. R. EvansCaroline H Brennan

Abstract

Telomere length reflects cellular ageing. Increased telomere shortening in leukocytes is associated with a range of neurodegenerative and cardiovascular diseases, the onset and progression of which may be mediated by behavioural traits such as anxiety and stress reactivity. However, the effects of the hypothalamus-pituitary-adrenal axis stress response are shown to be tissue specific. As such, leukocyte telomere length may not give an accurate measure of the relationship between stress-reactivity and telomere length in disease relevant tissues. To test the hypothesis that stress-reactivity contributes to age-related telomere shortening in a tissue specific manner, we examined the correlation between telomere length in heart and brain tissue and stress-reactivity in a population of young (6-9 month) and ageing (18 month) zebrafish. Stress-reactivity was assessed by tank diving, a zebrafish version of the rodent open-field test, and through gene expression. Telomere length was assessed using quantitative polymerase chain reaction. We show that ageing zebrafish have shorter telomeres in both heart and brain. Telomere length is inversely related to stress-reactivity in heart but not brain of ageing individuals. These data support t...Continue Reading

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Mentioned in this Paper

Study
Brain Injuries
American
Central Neuroblastoma
Virus
Murine
Neurons
Chemokine
Persons
Cell Differentiation Process

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