The impact of age and ageing on hepatocarcinoma surgery: Short- and long-term outcomes in a multicentre propensity-matched cohort

Liver International : Official Journal of the International Association for the Study of the Liver
Simone FamularoLuciano De Carlis

Abstract

Management of malignancy in elderly patients is challenging. We aimed to assess the impact of age and ageing on overall survival (OS), recurrence-free survival (RFS), tumour-specific survival (TSS) and potential years of life lost (PYLL) after surgery for hepatocarcinoma (HCC). Consecutive patients treated for HCC between 2005 and 2015 were evaluated. Patients were divided according to age-decade. Afterwards, elderly patients (≥75 years) were compared with patients < 75 years. A 1:1 propensity matching was used to reduce the risk of bias. Survival was estimated by Kaplan-Meier method and Cox regression analysis. Four hundred and thirty-nine patients were stratified: group 1 (age ≤ 55, n = 72), group 2 (age: 56-65, n = 133), group 3 (age: 66-74, n = 141) and group 4 (age ≥ 75, n = 93). Group 1 had the highest median PYLL (27.6, IQR 24.6-32.5) while group 4 the lowest (2.0, IQR 0-9.6; P < 0.001). Comparing elderly vs younger, there were no significant differences in terms of OS (P = 0.054), TSS (P = 0.321) and RFS (P = 0.240). Ageing was the only variable associated with post-operative complications (OR: 2.51; 95% CI: 1.23-5.13; P = 0.025) and liver-related morbidity was an independent predictor of OS. (HR 2.49, 95% CI: 1.34-4.64...Continue Reading

References

Jun 1, 1977·International Journal of Epidemiology·J M Romeder, J R McWhinnie
Jul 1, 1990·Epidemiology·J W Gardner, J S Sanborn
Feb 1, 1990·Annals of Surgery·J G Fortner, R M Lincer
Feb 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H A WynneO F James
Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G MarchesiniE Pisi
Feb 5, 1998·Lancet·S DeufficA J Valleron
Apr 15, 1999·Age and Ageing·M ZoliG Marchesini
Aug 9, 2005·World Journal of Surgery·Henrik Petrowsky, Pierre-Alain Clavien
Sep 25, 2007·Medical Care·Jack Needleman, Peter I Buerhaus
Sep 25, 2007·Medical Care·Jeffrey H SilberKevin G Volpp
Nov 28, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masatoshi MakuuchiYoshio Yamaoka
Oct 3, 2009·The New England Journal of Medicine·Amir A GhaferiJustin B Dimick
Jan 27, 2010·The British Journal of Surgery·R AdamUNKNOWN LiverMetSurvey Centres
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Jul 16, 2011·Journal of Hepatology·Valentina SantiFranco Trevisani
Sep 3, 2011·Techniques in Coloproctology·D SymeonidisK Tepetes
Jul 20, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Cho Rok LeeKyung Sik Kim
Jan 23, 2013·Social Science & Medicine·Johan P Mackenbach
Jul 25, 2013·American Journal of Surgery·Thomas N RobinsonMarc Moss
Aug 21, 2013·World Journal of Surgery·Yanming ZhouBin Li
Oct 1, 2014·The Journal of Surgical Research·Louis M RevenigViraj A Master
Nov 12, 2014·World Journal of Gastroenterology : WJG·Koichi OishiMikiya Kitamoto
Jan 15, 2015·Annals of Surgical Oncology·Norihiro KishidaYuko Kitagawa
Nov 18, 2015·World Journal of Gastroenterology : WJG·Annie K Hung, Jennifer Guy
Dec 15, 2015·The British Journal of Surgery·A CucchettiV Mazzaferro
Jan 26, 2016·Journal of the American Medical Directors Association·Matteo CesariBruno Vellas
Nov 1, 2016·Anticancer Research·Karel SmetanaAleksi Šedo
Jan 14, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Roberto SantambrogioEnrico Opocher
Apr 10, 2018·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Jun 5, 2018·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Simone FamularoLuciano De Carlis

❮ Previous
Next ❯

Citations

Jun 20, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Yi-Xuan ZhangPing Liang
Mar 10, 2021·Updates in Surgery·Yueh-Wei LiuYi-Hao Yen
Apr 4, 2021·Pharmaceuticals·Piera FedericoBruno Daniele
Jan 15, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Simone FamularoLuciano De Carlis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.