The impact of age and frailty on ventricular structure and function in C57BL/6J mice

The Journal of Physiology
H A FeridooniSusan E Howlett

Abstract

Heart size increases with age (called hypertrophy), and its ability to contract declines. However, these reflect average changes that may not be present, or present to the same extent, in all older individuals. That aging happens at different rates is well accepted clinically. People who are aging rapidly are frail and frailty is measured with a 'frailty index'. We quantified frailty with a validated mouse frailty index tool and evaluated the impacts of age and frailty on cardiac hypertrophy and contractile dysfunction. Hypertrophy increased with age, while contractions, calcium currents and calcium transients declined; these changes were graded by frailty scores. Overall health status, quantified as frailty, may promote maladaptive changes associated with cardiac aging and facilitate the development of diseases such as heart failure. To understand age-related changes in heart structure and function, it is essential to know both chronological age and the health status of the animal. On average, cardiac hypertrophy and contractile dysfunction increase with age. Still, individuals age at different rates and their health status varies from fit to frail. We investigated the influence of frailty on age-dependent ventricular remodell...Continue Reading

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Citations

May 23, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alice E KaneSusan E Howlett
Jun 26, 2018·The Journal of Physiology·Samantha D Francis StuartCrystal M Ripplinger
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Sep 8, 2021·Circulation. Arrhythmia and Electrophysiology·Hailey J JansenRobert A Rose

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