The impact of age on intravesical instillation of Bacille Calmette-Guerin treatment in patients with high-grade T1 bladder cancer

Medicine
Beppe CalòLuigi Cormio

Abstract

Intravesical instillation of Bacille Calmette-Guèrin (BCG) is the standard adjuvant treatment for high-risk non muscle invasive bladder cancer (NMIBC). Since its mechanism of action is supposed to be linked to the immune system efficiency and senescence could negatively affect this efficiency, BCG efficacy in the elderly has been questioned. This study aimed to assess the impact of age on BCG efficacy and safety in patients with high-grade T1 bladder cancer (BC).Among 123 patients with high-grade T1 BCG scheduled for BCG treatment, 82 were <75 year-old (group A) and 41 were ≥75 year-old (group B). Follow-up: urine cytology and cystoscopy every 3 months for the first 2 years, every 6 months for the third year, and then yearly. Tumor recurrence was defined as pathological evidence of disease at the bladder biopsy; tumor progression was defined as pathological shift to muscle invasive disease at the bladder biopsy or the imaging techniques showing recurrent BC and distant metastasis likely related to it.The median follow-up was 65 months (range 11-152). Recurrence occurred in 35 patients, 19 (23.2%) in the group A and 16 (39%) in the group B. Progression occurred in 18 patients, 12 (14.6%) in the group A and 6 (14.6%) in the group...Continue Reading

References

Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Jul 19, 2014·Critical Reviews in Clinical Laboratory Sciences·Francesca SanguedolceLuigi Cormio
Jun 9, 2015·Critical Reviews in Clinical Laboratory Sciences·Francesca SanguedolceLuigi Cormio
Jul 3, 2016·European Urology·Sebastien AntoniFreddie Bray
Aug 16, 2017·Critical Reviews in Oncology/hematology·Antonella CormioLuigi Cormio
Jan 16, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Francesca SanguedolceLuigi Cormio
Jan 25, 2018·Journal of Cancer Research and Clinical Oncology·Francesca SanguedolceLuigi Cormio

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BETA
biopsy
imaging techniques

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STATA SE
MedCalc

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