The impact of aging and atherosclerotic risk factors on transthoracic coronary flow reserve in subjects with normal coronary angiography.

Cardiovascular Ultrasound
Maurizio GalderisiEugenio Picano

Abstract

Age may affect coronary flow reserve (CFR) especially in subjects with atherosclerotic risk factors (ARFs). The aim of this prospective, multicenter, observational study was to determine the effects of aging on CFR in patients with normal epicardial coronary arteries and ARFs. Three-hundred-thirty-five subjects (mean age = 61 years) with at least one ARF but normal coronary angiography underwent high-dose dipyridamole stress-echo with Doppler evaluation of left anterior descending artery. CFR was calculated as the ratio between hyperemic and resting coronary diastolic peak velocities. Patients were divided in age quartiles. CFR was progressively reduced with aging (1st quartile: 3.01 ± 0.69, 4th quartile: 2.39 ± 0.49, p < 0.001). This was mainly due to a gradual increase of resting velocities (1st quartile = 26.3 ± 6.1 cm/s, 4th quartile = 30.2 ± 6.4 cm/s, p < 0.001) while the reduction of hyperemic velocities remained unaffected (1st quartile = 77.7 ± 18.9 cm/s, 4th quartile = 70.9 ± 18.4 cm/s, NS). When age quartiles and ARFs were entered into a regression model, third and fourth age quartile (p < 0.0005 and p < 0.0001 respectively), left ventricular mass index (p < 0.0001), diastolic blood pressure (p < 0.001), total cholest...Continue Reading

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Citations

Sep 6, 2015·Cardiovascular Ultrasound·Miodrag DikicAleksandra Arandjelovic
May 27, 2014·International Journal of Cardiology·Eugenio PicanoUbaldo Bonuccelli
Jan 11, 2014·The American Journal of Cardiology·Sari ImamuraTakashi Akasaka
Dec 15, 2015·Journal of Cardiovascular Medicine·Chiara AnchisiElena Grossini
Aug 2, 2017·Antioxidants & Redox Signaling·Amanda J LeBlanc, Natia Q Kelm
Feb 1, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·François DérimayWilliam F Fearon
May 21, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Chris NevittAmanda LeBlanc
Jan 18, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Valérie Elise StegehuisTim P van de Hoef
Jan 21, 2021·Coronary Artery Disease·Monica VerdoiaUNKNOWN Novara Atherosclerosis Study Group (NAS)

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