The impact of alcohol dependence on social brain function

Addiction Biology
Elke R GizewskiBoris Schiffer

Abstract

The impact of alcoholism (ALC) or alcohol dependence on the neural mechanisms underlying cognitive and affective empathy (i.e. the different routes to understanding other people's minds) in schizophrenic patients and non-schizophrenic subjects is still poorly understood. We therefore aimed at determining the extent to which the ability to infer other people's mental states and underlying neural mechanisms were affected by ALC. We examined 48 men, who suffered either from ALC, schizophrenia, both disorders or none of these disorders, using functional magnetic resonance imaging while performing on a mind reading task that involves both cognitive and affective aspects of empathy. Using voxel-based morphometry, we additionally examined whether between-group differences in functional activity were associated with deficits in brain structural integrity. During mental state attribution, all clinical groups as compared with healthy controls exhibited poor performance as well as reduced right-hemispheric insular function with the highest error rate and insular dysfunction seen in the schizophrenic patients without ALC. Accordingly, both behavioral performance and insular functioning revealed schizophrenia × ALC interaction effects. In a...Continue Reading

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Citations

Jan 13, 2016·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Roy C OnuohaAdam J Guastella
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Aug 20, 2018·Psychiatry Research. Neuroimaging·Margaret QuinnStephan Heckers

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