The impact of aluminum, fluoride, and aluminum-fluoride complexes in drinking water on chronic kidney disease

Environmental Science and Pollution Research International
Hewa M S WasanaJayasundera Bandara

Abstract

It is suspected that drinking water containing fluoride and aluminum results in negative health effects especially on brain, liver, and kidney. In this investigation, the effect of F, Al, and AlFx complex on chronic kidney disease (CKD) was investigated. Mice were treated either with WHO recommended or slightly higher F and Al levels in drinking water. Treatment solutions contained 0.05-10.0 mg/L of F, 0.08-10.0 mg/L of Al, or 0.07-15 mg/L of AlFx, and the treatment period was 42 weeks. Blood urea level and creatinine levels were investigated as a measure of malfunction of kidneys. Histopathological evaluations of kidney tissues were carried out to assess the extent of damage that F, Al, and AlFx complex could cause. It was demonstrated that the treated drinking water containing F and Al with par with WHO or moderately above the WHO levels or AlFx in low level (0.07-15 mg/L) does not lead to CKD in mice.

References

Jul 1, 1975·The Histochemical Journal·S L ManochaZ L Olkowski
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J ZhouJ Douglas
Jan 15, 1990·The Biochemical Journal·F RenduS Levy-Toledano
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·M R Wills, J Savory
Apr 22, 1972·Lancet·H ThurstonJ D Swales
Mar 30, 1981·Toxicology and Applied Pharmacology·H SpencerE Wiatrowski
Nov 16, 2001·Journal of Inorganic Biochemistry·M SargaziA Shenkin
Mar 21, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jorge B Cannata-Andía, Jose L Fernández-Martín
May 11, 2002·The Tohoku Journal of Experimental Medicine·Junko ChibaSeizaburo Sakamoto
Jan 25, 2005·Lancet·A Meguid El Nahas, Aminu K Bello
Aug 8, 2006·Nephrology·Igor CodreanuGiuseppe Remuzzi
Oct 5, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Helmut Schiffl
Aug 30, 2008·The Annals of Pharmacotherapy·Rex O BrownRoland N Dickerson
Jun 23, 2009·Drug and Chemical Toxicology·Tanzeer KaurBimla Nehru
Nov 4, 2009·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Vineet Dhar, Maheep Bhatnagar
May 5, 2010·Advances in Chronic Kidney Disease·Peter SoderlandJames S Kaufman
Sep 21, 2010·Environmental Geochemistry and Health·Rohana ChandrajithAkio Koizumi
Sep 23, 2010·Archives of Toxicology·Ansuman ChattopadhyayShelley Bhattacharya
Jul 6, 2011·BMC Nephrology·Kamani P WanigasuriyaRajitha Wickremasinghe
Jan 1, 2013·Environmental Toxicology and Pharmacology·Y Z ZhuY F Li

❮ Previous
Next ❯

Citations

Sep 6, 2015·Journal of Inorganic Biochemistry·Anetta Zioła-FrankowskaMarcin Frankowski
Jan 31, 2020·Environmental Geochemistry and Health·Sunil J Wimalawansa
Dec 29, 2020·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Ranaa Aqeelah Faleel, Uthpala Apekshani Jayawardena
Jun 3, 2021·International Journal of Environmental Research and Public Health·Adriano CasagliaLoredana Cerroni
Nov 21, 2021·Environmental Science and Pollution Research International·Dinushi ArambegedaraPreethi Udagama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon Jinzo Gakkai shi
Seiichi Matsuo
Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
Younis A SalmeanWendy J Dahl
Bulletin of Environmental Contamination and Toxicology
E M Turnquest, W H Hallenbeck
© 2021 Meta ULC. All rights reserved