The Impact of Atrial Left-to-Right Shunt on Pulmonary Hypertension in Preterm Infants with Moderate or Severe Bronchopulmonary Dysplasia

Pediatrics and Neonatology
Eui Kyung ChoiJung-Hwan Choi

Abstract

Bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH) is a well-known complication of prematurity; however, the additional impact of a left-to-right interatrial shunt on this condition remains poorly understood. The aim of the present study was to identify the significance of atrial left-to-right shunt lesions in PH infants with moderate or severe BPD. The medical records of 383 preterm infants (gestational age of < 32 weeks) who were diagnosed with BPD between 2005 and 2013 were retrospectively reviewed. Baseline characteristics such as interatrial shunts and outcomes were compared between the infants who developed PH (n = 50) and infants who did not (n = 144). Infants with hemodynamically significant residual patent ductus arteriosus were excluded. Among the infants diagnosed with PH (n = 50), the outcomes were compared between the patients with (n = 21) and without atrial shunts (n = 29) at 36 weeks corrected postmenstrual age. Fifty (15%) preterm infants with BPD were diagnosed with PH. The number of infants with a history of atrial shunt lesions was significantly higher in the PH group than in the non-PH group (42% vs. 15.3%, respectively). The adjusted odds ratio for PH in the atrial shunt group was 3.8 ...Continue Reading

References

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Citations

Nov 11, 2018·Paediatric Anaesthesia·Gregory J Latham, Delphine Yung
Apr 3, 2019·Pediatric Pulmonology·Martina A SteurerRoberta L Keller
Jan 13, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·G Al-GhanemA Mukerji
Dec 25, 2019·Pediatric Allergy, Immunology, and Pulmonology·Nidhy Varghese, Danielle Rios
Apr 5, 2016·Current Opinion in Pediatrics·Michael Glenn O'ConnorEric D Austin
Dec 12, 2018·Frontiers in Pediatrics·Shilpa Vyas-ReadUsama Kanaan
Oct 7, 2021·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Minqiao JianCaisheng Liu

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