The Impact of Autoantibodies on IVF Treatment and Outcome: A Systematic Review

International Journal of Molecular Sciences
Mara SimopoulouMichael Koutsilieris

Abstract

The role of autoantibodies in in vitro fertilization (IVF) has been discussed for almost three decades. Nonetheless, studies are still scarce and widely controversial. The aim of this study is to provide a comprehensive systematic review on the possible complications associated to autoantibodies (AA) impeding the chances of a successful IVF cycle. An Embase, PubMed/Medline and Cochrane Central Database search was performed on 1 December 2018, from 2006 until that date. From the 598 articles yielded in the search only 44 relevant articles ultimately fulfilled the inclusion criteria and were qualitatively analyzed. Five subsets of results were identified, namely, thyroid related AA, anti-phospholipid antibodies, anti-nuclear antibodies, AA affecting the reproductive system and AA related to celiac disease. It may be implied that the majority of auto-antibodies exert a statistically significant effect on miscarriage rates, whereas the effects on clinical pregnancy and live birth rates differ according to the type of auto-antibodies. While significant research is performed in the field, the quality of evidence provided is still low. The conduction of well-designed prospective cohort studies is an absolute necessity in order to defi...Continue Reading

References

Aug 12, 1978·Lancet·P C Steptoe, R G Edwards
Aug 1, 1989·American Journal of Obstetrics and Gynecology·P V TaylorJ S Scott
May 1, 1994·Clinical Endocrinology·G E KrassasM Batrinos
May 8, 1998·The New England Journal of Medicine·B H Hahn
Sep 1, 1999·Clinical Endocrinology·G E KrassasL H Duntas
Sep 29, 1999·Rheumatology·M R Ehrenstein
May 20, 2000·Annals of the New York Academy of Sciences·A G Doufas, G Mastorakos
Sep 7, 2001·Journal of Reproductive Immunology·K ReimandR Uibo
Dec 20, 2002·Thyroid : Official Journal of the American Thyroid Association·Kris PoppeBrigitte Velkeniers
Apr 26, 2006·American Journal of Reproductive Immunology : AJRI·Hidehiko MatsubayashiJohn A McIntyre
Dec 13, 2006·American Journal of Reproductive Immunology : AJRI·Sa-Ra LeeByung-Moon Kang
Jun 15, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Marcos AbalovichOscar Levalle
Jan 18, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Sandro C EstevesSidney Verza
Nov 26, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sevtap KilicSertac Batioglu
May 27, 2009·Current Opinion in Obstetrics & Gynecology·Amy M Cline, William H Kutteh
Dec 4, 2009·European Journal of Endocrinology·Konstantinos A ToulisIoannis Papadimas
Feb 6, 2010·American Journal of Reproductive Immunology : AJRI·Aili SarapikRaivo Uibo
Nov 30, 2010·Journal of Reproductive Immunology·Armand ZiniSimon Phillips
Jan 19, 2011·American Journal of Reproductive Immunology : AJRI·Patrizia MonteleonePaolo Giovanni Artini
Feb 8, 2011·Fertility and Sterility·Kyoko ShirotaShingo Miyamoto
Mar 4, 2011·Seminars in Thrombosis and Hemostasis·Lothar HeilmannJawed Fareed
Jun 11, 2011·International Journal of Immunopathology and Pharmacology·D CaccavoR Depalo
Jul 19, 2011·American Journal of Reproductive Immunology : AJRI·Yi-Ping ZhongJing Li
Jul 12, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A RagabA Badawy
Sep 15, 2012·Journal of Assisted Reproduction and Genetics·Alex Simon, Neri Laufer
Feb 15, 2013·Thyroid : Official Journal of the American Thyroid Association·David UnuaneKris Poppe
Mar 14, 2013·American Journal of Reproductive Immunology : AJRI·Ying YingXiao-Ting Shen

❮ Previous
Next ❯

Citations

Apr 30, 2020·American Journal of Reproductive Immunology : AJRI·Asmaa BeltagyCecilia B Chighizola
Dec 11, 2019·American Journal of Reproductive Immunology : AJRI·Marcelo Borges CavalcanteRicardo Barini
Oct 20, 2020·Systems Biology in Reproductive Medicine·Fang LiuXiaoli Yang
Dec 6, 2020·American Journal of Reproductive Immunology : AJRI·Kamila KolanskaArsene Mekinian
Oct 21, 2019·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Marit L Bovbjerg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.