The impact of baseline [-2]proPSA-related indices on the prediction of pathological reclassification at 1 year during active surveillance for low-risk prostate cancer: the Japanese multicenter study cohort

Journal of Cancer Research and Clinical Oncology
Hiromi HiramaYoshiyuki Kakehi

Abstract

Active surveillance (AS) is one potential solution to avoiding the overtreatment of favorable prostate cancer. By handling the AS strategy more safely, tumor aggressiveness may be evaluated more accurately. The aim of the present study was to evaluate the predictive impact of baseline prostate-specific antigen (PSA) isoform [-2]proPSA (p2PSA)-related indices on the pathological reclassification at 1 year during an AS program. Between 2002 and 2003, 134 males diagnosed with low-risk prostate cancer were registered in the Japanese multicenter study cohort as candidates for AS, and 118 (88 %) males actually proceeded to AS. Of the 118 patients, the 67 that underwent protocol biopsy at 1 year after beginning AS were enrolled in the present study. The predictive significance of various baseline clinicopathological features and p2PSA-related indices on pathological reclassification at 1 year after beginning AS were investigated. The pathological reclassification rate was 37.3 %. According to the univariate analysis, prostate volume (p = 0.049), number of biopsy cores (p = 0.047), percentage of positive biopsy cores (p = 0.023), p2PSA to free PSA ratio (%p2PSA) (p = 0.003) and prostate health index (phi) (p = 0.010) at baseline were s...Continue Reading

References

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Aug 21, 2012·The Journal of Urology·Jeffrey J TosoianLori J Sokoll

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Citations

Aug 20, 2014·International Journal of Clinical Oncology·Kazuto ItoBernard Cook
Jan 16, 2016·Future Oncology·Matteo FerroOttavio De Cobelli
Dec 2, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Javier Romero-OteroKarim A Touijer
May 12, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Koji MitsuzukaSeiji Naito
Nov 29, 2015·The Urologic Clinics of North America·Abbey LeporStacy Loeb
Mar 10, 2016·Nature Reviews. Urology·Jeffrey J TosoianStacy Loeb
Apr 2, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Koji OkiharaKazuto Ito
Sep 5, 2015·BioMed Research International·Jeong Hyun Kim, Sung Kyu Hong
Dec 3, 2014·The Journal of Urology·Stacy LoebWilliam J Catalona
Oct 16, 2016·BJU International·Stacy LoebWilliam J Catalona
Mar 2, 2017·International Journal of Molecular Sciences·Frank FriedersdorffErgin Kilic
Jun 2, 2016·American Society of Clinical Oncology Educational Book·Jeffrey J TosoianEdward M Schaeffer
Feb 15, 2020·International Journal of Molecular Sciences·Matteo FerroDaniela Terracciano
Jun 5, 2016·Current Opinion in Urology·Stacy LoebAndrew Vickers
Mar 3, 2015·Current Opinion in Urology·Andrew S Behesnilian, Robert E Reiter
Feb 24, 2015·Current Opinion in Urology·Masaki KimuraShigeo Horie
Dec 30, 2016·Future Science OA·Pranav SharmaJulio M Pow-Sang
Mar 3, 2019·Der Urologe. Ausg. A·M ChaloupkaM Apfelbeck
Nov 7, 2017·The Urologic Clinics of North America·Stacy Loeb, Hasan Dani
Jul 3, 2021·International Journal of Molecular Sciences·Belén Pastor-NavarroJosé Antonio López-Guerrero

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Methods Mentioned

BETA
biopsies
biopsy

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