The impact of blood coagulability on atherosclerosis and cardiovascular disease

Journal of Thrombosis and Haemostasis : JTH
R LoeffenHugo ten Cate

Abstract

Although the link between blood coagulation and atherogenesis has been long postulated, only recently, and through the extensive work on transgenic mice, crossbred on an atherogenic background, has the direction of this interaction become visible. In general, hypercoagulability in mice tends to increase atherosclerosis, whereas hypocoagulability reduces the atherosclerotic burden, depending on the mouse model used. The information on a direct relationship between coagulation and atherosclerosis in humans, however, is not that clear. Almost all coagulation proteins, including tissue factor, are found in atherosclerotic lesions in humans. In addition to producing local fibrin, a matrix for cell growth, serine proteases such as thrombin may be very important in cell signaling processes, acting through the activation of protease-activated receptors (PARs). Activation of PARs on vascular cells drives many complex processes involved in the development and progression of atherosclerosis, including inflammation, angiogenesis, and cell proliferation. Although current imaging techniques do not allow for a detailed analysis of atherosclerotic lesion phenotype, hypercoagulability, defined either by gene defects of coagulation proteins or e...Continue Reading

References

Apr 1, 1976·British Journal of Haematology·D L RichardsonA B Kay
Mar 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·E B SmithC Stirk
Jan 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A BiniK L Kaplan
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J N WilcoxD Gordon
Dec 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R LassilaV Manninen
Sep 1, 1993·The Journal of Clinical Investigation·H ten CateR D Rosenberg
May 3, 1996·Science·J L Breslow
Apr 16, 1998·The Journal of Clinical Investigation·Q XiaoJ L Degen
Apr 8, 1998·British Journal of Haematology·F B SmithG D Lowe
Sep 22, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·P A PriceM K Williamson
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·X J LouR M Lawn
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jun 22, 1999·The New England Journal of Medicine·G D Sloop
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·H AndersenE W Davie
Dec 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·W M CheungB P Damiano
Nov 14, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·M C MinnemaH ten Cate
Jan 30, 2002·The American Journal of the Medical Sciences·Alan Daugherty
Jun 19, 2002·Blood·Klaus JuulBørge Grønne Nordestgaard
Nov 30, 2002·Trends in Cardiovascular Medicine·Alexey V KhrenovEvgueni L Saenko
Dec 20, 2002·Nature·Peter Libby
Jan 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Josiah N WilcoxJuan Casanova
Sep 25, 2003·Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan·Yasuyoshi YoshiiHidemi Ishii
Mar 17, 2004·Current Opinion in Lipidology·Barbara Voetsch, Joseph Loscalzo
Mar 30, 2004·Thrombosis Journal·Ertugrul ErcanUnal Acikel

❮ Previous
Next ❯

Citations

Jul 13, 2013·Current Opinion in Rheumatology·Jason S Knight, Mariana J Kaplan
Sep 18, 2013·Hämostaseologie·K A KrychtiukJ Wojta
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Natalia I Dmitrieva, Maurice B Burg
Nov 19, 2013·Journal of Thrombosis and Thrombolysis·Jana KalzHenri M H Spronk
Sep 13, 2013·Current Atherosclerosis Reports·Henri M H SpronkHugo ten Cate
May 2, 2013·Blood Reviews·Kristien WinckersTilman M Hackeng
Oct 31, 2012·Journal of Thrombosis and Haemostasis : JTH·A GirolamiA M Lombardi
Dec 11, 2014·IUBMB Life·Miriam Koch, Alma Zernecke
May 21, 2013·Journal of Diabetes·Yunjuan ZhaoZhiguang Zhou
Mar 7, 2014·Journal of Thrombosis and Haemostasis : JTH·H Ten Cate, T Meade
Jan 22, 2013·Current Opinion in Pharmacology·Vincenzo JacomellaMarc Husmann
Oct 22, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Douglas B Kell, Etheresia Pretorius
Apr 20, 2016·Journal of Hepatology·Sven M FrancqueWilhelmus J Kwanten
Feb 22, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·A D ShapiroG A Allen
Apr 13, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Alexander MilgromCharles J Glueck
Apr 30, 2017·Journal of Thrombosis and Haemostasis : JTH·R G HoltD B Khismatullin
Feb 17, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Nigel MackmanHugo Ten Cate
Feb 26, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Nigel Mackman
Jan 23, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Reut Shnerb GanorOphira Salomon
Dec 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Jens J PosmaNigel Mackman
Dec 25, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Julio M Martinez-MorenoYolanda Almaden
Nov 29, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ahmed AmaraBrahim Nsiri
Nov 23, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Roland von KänelMarcus Ising
Nov 9, 2019·Journal of Food Biochemistry·Abdullah S ShatoorSultan A Alqahtani
Apr 4, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Roland von KänelBrent T Mausbach
Jul 30, 2020·Journal of Food Biochemistry·Huda H SattiDalia G Mostafa
Jul 22, 2020·Pediatric Diabetes·Hildegard Jasser-NitscheAxel Schlagenhauf
Feb 26, 2019·Frontiers in Cardiovascular Medicine·Grzegorz B WasilewskiLeon J Schurgers
Dec 26, 2018·Interdisciplinary Sciences, Computational Life Sciences·Kaja GutowskaPiotr Formanowicz
Apr 8, 2020·Vascular·Abdelrahman ZamzamMohammad Qadura
Jun 15, 2020·Current HIV/AIDS Reports·Aaren KettelhutNicholas T Funderburg

❮ Previous
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