The impact of body weight on the diagnosis of aortic dilation-misdiagnosis in overweight and underweight groups

Echocardiography
Katherine T BraleyRonnie T Collins

Abstract

Body surface area (BSA)-indexed Z-scores are used to assess the ascending aorta (AAo) and diagnose aortic dilation (AoD) in children. BSA is directly related to body weight and corresponds to body mass index (BMI). We hypothesized extremes in BMI alter interpretation of aortic size in pediatric patients with AoD. We reviewed all echocardiograms with a diagnosis of AoD performed at our institution from January 2013 through June 2013. Those with an age <2 or >20 years, history of aortic root surgery, or inadequate images were excluded. The aorta was measured by standard methods at the sinus of Valsalva, sinotubular junction, and proximal AAo. Using subject age, height, and gender, hypothetical weights for each subject were calculated to provide BMIs corresponding to the 5th, 50th, 85th, and 95th percentiles. The derived weights were then used to determine hypothetical BSA, and Z-scores were calculated for the subject's aortic diameters in each BMI group. A total of 153 patients met inclusion criteria. Mean age was 11.1±4.6 years (68% male). Mean height was 142.7±27.9 cm, mean weight 44.6±24.8 kg, and mean true BMI was the 62nd centile. Significant differences in all aortic dimension Z-scores were found among normal and underweigh...Continue Reading

References

Feb 1, 1978·Circulation·C L RogéR M Ray
Jan 1, 1992·Scandinavian Journal of Thoracic and Cardiovascular Surgery·H Sairanen, I Louhimo
Apr 1, 1992·Journal of the American College of Cardiology·S M NidorfA E Weyman
Mar 1, 1990·The American Journal of Cardiology·H P Gutgesell, C M Rembold
Sep 1, 1989·The American Journal of Cardiology·M J RomanJ O'Loughlin
Jan 1, 1987·Pediatric Cardiology·L A LesterR A Arcilla
Nov 1, 1983·Journal of the American College of Cardiology·I SchnittgerR L Popp
Mar 1, 1993·The American Journal of Cardiology·C M ReedB S Alpert
Jan 11, 2003·The American Journal of Cardiology·Peter G DaniasWarren J Manning
Jul 5, 2003·The American Journal of Cardiology·Gian M NovaroBrian P Griffin
Aug 14, 2003·Clinical Physiology and Functional Imaging·Tuija PoutanenEero Jokinen
Nov 24, 2004·Journal of Applied Physiology·Thierry Sluysmans, Steven D Colan
Sep 1, 2005·Current Problems in Cardiology·Alan C BravermanMarc R Moon
Jan 24, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alessandro Della CorteMaurizio Cotrufo
Aug 8, 2007·The International Journal of Cardiovascular Imaging·Attila NemesMiklós Csanády
Apr 15, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Michael D PettersenRichard A Humes
Mar 10, 2010·The American Journal of Cardiology·Mathieu GautierGuillaume Jondeau
Nov 22, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Massimiliano CantinottiClaudio Passino
Jan 12, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Roland R J van KimmenadeJanneke Timmermans
Jan 23, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Anne E DavisOliver J Rider
Feb 27, 2014·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Apr 9, 2014·JAMA Pediatrics·Asheley Cockrell Skinner, Joseph A Skelton
Nov 13, 2014·Pediatric Cardiology·Frederic DallaireNagib Dahdah
Jan 7, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M LangJens-Uwe Voigt

❮ Previous
Next ❯

Citations

Oct 26, 2018·Circulation. Genomic and Precision Medicine·Michael SilberbachUNKNOWN American Heart Association Council on Cardiovascular Disease in the Young; Council on Genomic and Precision Medicine; and Co
Dec 23, 2020·The American Journal of Cardiology·Sherif ElkinanyJohn A Elefteriades
Mar 25, 2021·International Journal of Cardiology·Jose M SiuranaUNKNOWN group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.