The Impact of Caloric and Non-Caloric Sweeteners on Food Intake and Brain Responses to Food: A Randomized Crossover Controlled Trial in Healthy Humans

Nutrients
Camille CrézéUlrike Toepel

Abstract

Whether non-nutritive sweetener (NNS) consumption impacts food intake behavior in humans is still unclear. Discrepant sensory and metabolic signals are proposed to mislead brain regulatory centers, in turn promoting maladaptive food choices favoring weight gain. We aimed to assess whether ingestion of sucrose- and NNS-sweetened drinks would differently alter brain responses to food viewing and food intake. Eighteen normal-weight men were studied in a fasted condition and after consumption of a standardized meal accompanied by either a NNS-sweetened (NNS), or a sucrose-sweetened (SUC) drink, or water (WAT). Their brain responses to visual food cues were assessed by means of electroencephalography (EEG) before and 45 min after meal ingestion. Four hours after meal ingestion, spontaneous food intake was monitored during an ad libitum buffet. With WAT, meal intake led to increased neural activity in the dorsal prefrontal cortex and the insula, areas linked to cognitive control and interoception. With SUC, neural activity in the insula increased as well, but decreased in temporal regions linked to food categorization, and remained unchanged in dorsal prefrontal areas. The latter modulations were associated with a significantly lower...Continue Reading

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Citations

Apr 16, 2019·Nutritional Neuroscience·Marion A StopyraJoe J Simon
Jun 27, 2020·Current Nutrition Reports·Alexandra G YunkerKathleen A Page
Oct 30, 2020·International Journal of General Medicine·Ahmed Abdulrahman Alsunni
Aug 19, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M A StopyraJ J Simon

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Clinical Trials Mentioned

NCT02853773

Software Mentioned

LAURA
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