The Impact of Centrosome Pathologies on Prostate Cancer Development and Progression

Advances in Experimental Medicine and Biology
Heide Schatten, Maureen O Ripple

Abstract

The significant role of centrosomes in cancer cell proliferation has been well recognized (reviewed in Schatten H, Histochem Cell Biol 129:667-86 (2008); Schatten H, Sun Q-Y, Microsc Microanal 17(4):506-512 (2011); Schatten H, Sun Q-Y, Reprod Fertil Dev. https://doi.org/10.1071/RD14493 (2015a); Schatten H, Sun Q-Y, Centrosome-microtubule interactions in health, disease, and disorders. In: Schatten H (ed) The cytoskeleton in health and disease. Springer Science+Business Media, New York (2015b)) and new research has generated new interest and new insights into centrosomes as potential targets for cancer-specific therapies. The centrosome is a key organelle serving multiple functions through its primary functions as microtubule organizing center (MTOC) that is also an important communication center for processes involved in cellular regulation; transport to and away from centrosome-organized microtubules along microtubules is essential for cellular activities including signal transduction and metabolic activities. New research on cancer cell centrosomes has generated new insights into centrosome dysfunctions in cancer cells in which centrosome phosphorylation, balance of centrosomal proteins, centrosome regulation and duplication ...Continue Reading

Citations

Sep 22, 2020·Evolutionary Applications·Kenneth J PientaSarah R Amend
Apr 12, 2020·Trends in Molecular Medicine·Andrea RemoMassimo Pancione

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