The Impact of Cerebral Amyloid Angiopathy in Various Neurodegenerative Dementia Syndromes: A Neuropathological Study

Neurology Research International
J De Reuck

Abstract

The Boston criteria for cerebral amyloid angiopathy (CAA) have to be confirmed by postmortem examination. The present study investigates the incidence and the cerebrovascular impact of the severity of CAA in various neurodegenerative dementia diseases. 208 patients underwent an autopsy. They consisted of 92 brains with Alzheimer's disease (AD), 46 with frontotemporal lobar degeneration (FTLD), 24 with progressive supranuclear palsy (PSP), 21 with Lewy body dementia (LBD), 5 with corticobasal degeneration (CBD), and 20 controls. In addition to the macroscopic examination, a whole coronal section of a cerebral hemisphere, at the level of the mamillary body, was taken for semiquantitative microscopic evaluation of the small cerebrovascular lesions. CAA is present in 2/3% of the AD brains of which half of them have a severe form, grade 3. Only the latter displays more cerebrovascular lesions. CAA is present in 45% of the LBD brains. Cortical microinfarcts are only more frequent in the CAA grade 3 group. In LBD additional AD pathology is present in 41% of the CAA grade 0, 83% in grade 1-2, and 100% in grade 3. In PSP only 21% had CAA grade 1-2. In FTLD, CBD, and normal controls no CAA pathology is observed. The present study shows t...Continue Reading

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Citations

Jul 29, 2019·Current Neurology and Neuroscience Reports·Carolyn AkersMatthew Schrag
Jul 7, 2019·Brain Sciences·George P ParaskevasElisabeth Kapaki
May 1, 2021·Journal of Neural Transmission·Kurt A Jellinger
Jun 1, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Lieke JäkelMarcel M Verbeek
Dec 20, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Zina HijaziRosie Watson

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