The Impact of Childhood Adversity on the Clinical Features of Schizophrenia

Schizophrenia Research and Treatment
Ravi Philip Rajkumar

Abstract

Introduction. Recent research has drawn attention to the link between childhood maltreatment and schizophrenia. Child abuse and neglect may have an impact on symptoms and physical health in these patients. This association has not been studied to date in India. Materials and Methods. Clinically stable patients with schizophrenia (n = 62) were assessed for childhood adversity using the Childhood Trauma Questionnaire. The association of specific forms of adversity with symptomatology and associated variables was examined. Results. Emotional abuse was reported by 56.5% patients and physical abuse by 33.9%; scores for childhood neglect were also high. Persecutory delusions were linked to physical abuse, while anxiety was linked to emotional neglect and depression to emotional abuse and childhood neglect. Physical abuse was linked to elevated systolic blood pressure, while emotional abuse and neglect in women were linked to being overweight. Conclusions. Childhood adversity is common in schizophrenia and appears to be associated with a specific symptom profile. Certain components of the metabolic syndrome also appear to be related to childhood adversity. These results are subject to certain limitations as they are derived from remit...Continue Reading

References

Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Aug 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·M G HavilandL R Woods
Aug 1, 1994·The American Journal of Psychiatry·D P BernsteinJ Ruggiero
Jan 9, 2004·CNS Spectrums·Linda M BiererLarry J Siever
Jun 9, 2007·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Adriane R RosaEduard Vieta
Oct 9, 2007·Acta Psychiatrica Scandinavica·A Uçok, S Bikmaz
Nov 16, 2007·Schizophrenia Bulletin·Sarah BendallPatrick D McGorry
Jan 22, 2009·The Journal of Nervous and Mental Disease·I Alex RubinoAlberto Siracusano
Apr 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Helen FisherPaul Fearon
Apr 22, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Paul BebbingtonRachel Jenkins
Jun 19, 2012·Psychiatry Investigation·Lucia SideliRobin M Murray
Jun 22, 2012·Psychological Medicine·K DaalmanIris E C Sommer
Dec 1, 2012·Child Abuse & Neglect·Meeyoung O MinLynn T Singer
Feb 12, 2013·Clinical Schizophrenia & Related Psychoses·Bernard J Gallagher, Brian J Jones
Mar 1, 2013·Acta Psychiatrica Scandinavica·S AlemanyL Fañanás
Apr 30, 2013·Psychiatry Research·Catherine BortolonStéphane Raffard
Jul 3, 2013·Comprehensive Psychiatry·Julia M SheffieldStephan Heckers
Jul 24, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Monica AasIngrid Melle
Sep 26, 2013·Schizophrenia Bulletin·Jean-Paul SeltenElizabeth Cantor-Graae
Nov 21, 2013·Journal of Psychiatric Research·Melissa J GreenUNKNOWN Australian Schizophrenia Research Bank
Jun 10, 2014·Journal of Child Sexual Abuse·R K Jaishree Karthiga, Roopa Ravikumar
Jul 23, 2014·International Journal of Environmental Research and Public Health·Karl PeltzerAlexander Gasparishvili
Feb 28, 2015·The Australian and New Zealand Journal of Psychiatry·Michael DuhigJames Scott
Mar 27, 2015·Early Intervention in Psychiatry·Eugene RubyDolores Malaspina
Apr 22, 2015·Social Psychiatry and Psychiatric Epidemiology·Aleida FrissenUNKNOWN GROUP Investigators

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Citations

Mar 5, 2016·Child and Adolescent Psychiatry and Mental Health·Deanna L KellyRobert P McMahon
May 21, 2020·Frontiers in Psychiatry·Guttorm Breivik StorvestreUnn Kristin Haukvik
Mar 4, 2021·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·Laura NuñoMaite Barrios

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