The impact of chronic blackberry intake on the neuroinflammatory status of rats fed a standard or high-fat diet

The Journal of Nutritional Biochemistry
Manuela MeirelesConceição Calhau

Abstract

Neuroinflammation has been suggested as a central mediator of central nervous system dysfunction, including in dementia and neurodegenerative disease. Flavonoids have emerged as promising candidates for the prevention of neurodegenerative diseases and are thought to be capable of antiinflammatory effects in the brain. In the present study, the impact of a chronic intake of an anthocyanin extract from blackberry (BE) on brain inflammatory status in the presence or absence of a high-fat diet was investigated. Following intake of the dietary regimes for 17 weeks neuroinflammatory status in Wistar rat cortex, hippocampus and plasma were assessed using cytokine antibody arrays. In the cortex, intake of the high-fat diet resulted in an increase of at least 4-fold, in expression of the cytokine-induced neutrophil chemoattractant CINC-3, the ciliary neurotrophic factor CNTF, the platelet-derived growth factor PDGF-AA, IL-10, the tissue inhibitor of metalloproteinase TIMP-1 and the receptor for advanced glycation end products RAGE. BE intake partially decreased the expression of these mediators in the high-fat challenged brain. In standard-fed animals, BE intake significantly increased cortical levels of fractalkine, PDGF-AA, activin, t...Continue Reading

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Citations

Jan 18, 2016·Biological Psychiatry·Cláudia MarquesConceição Calhau
Mar 12, 2016·Behavioural Brain Research·Manuela MeirelesConceição Calhau
Jun 17, 2016·Molecular Nutrition & Food Research·Cláudia MarquesAna Faria
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberto MattioliPaula Silva
Apr 16, 2016·Immunity & Ageing : I & a·Sergio DavinelliGiovanni Scapagnini
Apr 9, 2020·Critical Reviews in Food Science and Nutrition·Giovana JamarLuciana Pellegrini Pisani
Jul 29, 2018·Scientific Reports·Cláudia MarquesConceição Calhau
Apr 4, 2021·International Journal of Molecular Sciences·Irina V MilanovaChun-Xia Yi
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Oksana Golovinskaia, Chin-Kun Wang

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