The impact of cinnarizine and griseofulvin on juvenile and adult stages of Schistosoma mansoni

Journal of Helminthology
R M SarhanSamia William

Abstract

Schistosomiasis affects millions globally. There is no vaccine, and treatment depends entirely on praziquantel (PZQ). Field isolates exhibit reduced susceptibility to PZQ, and resistance has been experimentally induced, suggesting that reliance on a single treatment is particularly dangerous. The present study investigated the value of cinnarizine and griseofulvin against Schistosoma mansoni through their in vitro effects on adult worms and oviposition as well as in vivo evaluation in early and late infection, compared to PZQ, in a preliminary experimental model. In vitro, both cinnarizine and griseofulvin showed uncoupling, sluggish worm movement and complete absence of ova at 100 μg/ml. In early infection, cinnarizine showed a significant reduction in the number of porto-mesenteric couples compared to the griseofulvin and control groups, a finding similar to PZQ. Remarkably, cinnarizine significantly exceeded PZQ and griseofulvin in reducing the total worm burden. In late infection, cinnarizine and griseofulvin showed results similar to PZQ by significantly reducing the numbers of hepatic and porto-mesenteric couples and total worm burden compared to controls. Cinnarizine performed better than griseofulvin by reducing hepatic...Continue Reading

References

Feb 1, 1988·Experimental Parasitology·M K Shaw, D A Erasmus
Jan 1, 1986·British Journal of Clinical Pharmacology·B N Singh
Jan 1, 1985·Pharmacology & Therapeutics·P Andrews
Jul 1, 1967·The American Journal of Tropical Medicine and Hygiene·R H Duvall, W B DeWitt
Oct 5, 2001·Memórias do Instituto Oswaldo Cruz·F NoëlD L Mendonça-Silva
Mar 1, 1962·The American Journal of Tropical Medicine and Hygiene·J PELLEGRINOA S CUNHA
Mar 12, 2004·International Journal for Parasitology·Livia Pica-Mattoccia, Donato Cioli
Apr 10, 2004·The Lancet Infectious Diseases·Dorothy Bonn
Jan 1, 1996·Parasitology Today·C A RedmanR J Martin
Dec 28, 2004·International Journal for Parasitology·Robert M Greenberg
Jun 1, 2005·Parasitology International·Wannee JiraungkoorskulNiwat Kangwanrangsan
Jul 9, 2005·International Journal for Parasitology·Sanaa BotrosDonato Cioli
Jan 18, 2007·Journal of Cellular Biochemistry·Yih-Huei UenShyr-Yi Lin
Nov 4, 2008·Current Opinion in Infectious Diseases·Michael J DoenhoffJürg Utzinger
Jan 7, 2009·PLoS Neglected Tropical Diseases·Jennifer KeiserMarcel Tanner
Sep 30, 2009·PLoS Neglected Tropical Diseases·Peter J Hotez, Alan Fenwick
Jan 5, 2012·Parasitology Research·Humberto Gonçalves BertãoGandhi Rádis-Baptista
May 15, 2012·Acta Tropica·David RollinsonJürg Utzinger
Jul 10, 2012·Experimental Parasitology·Rosimeire Nunes de OliveiraSilmara Marques Allegretti
Oct 12, 2012·Parasitology Research·Wei WangYou-Sheng Liang
Oct 1, 2007·Expert Opinion on Drug Discovery·Bernadette RamirezSolomon Nwaka
Apr 5, 2013·PLoS Neglected Tropical Diseases·Paul J Brindley, Peter J Hotez
Jul 3, 2013·Acta Tropica·Tarsila Ferraz FrezzaSilmara Marques Allegretti
Aug 2, 2013·Memórias do Instituto Oswaldo Cruz·Vanessa Silva-MoraesRafaella Fortini Queiroz Grenfell
Jan 7, 2014·PLoS Neglected Tropical Diseases·Josué de MoraesPedro L S Pinto
Mar 8, 2014·Experimental Parasitology·Rosimeire Nunes de OliveiraSilmara Marques Allegretti
Apr 5, 2014·Lancet·Daniel G ColleyCharles H King
Jun 24, 2014·Molecular and Biochemical Parasitology·Donato CioliAlessandra Guidi
May 23, 2015·Future Medicinal Chemistry·Conor R Caffrey
Mar 8, 2017·Antimicrobial Agents and Chemotherapy·Nuno ValeJosé M Correia da Costa
Mar 23, 2017·Memórias do Instituto Oswaldo Cruz·Reem Osama A Kamel, Fatma El-Zahraa Anwar Bayaumy

❮ Previous
Next ❯

Citations

Jun 4, 2020·Parasites & Vectors·Rogério P XavierJosué de Moraes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.