The Impact of Clinical and Pathological Features on Intraductal Papillary Mucinous Neoplasm Recurrence After Surgical Resection: Long-Term Follow-Up Analysis

Annals of Surgery
Michael J PflügerLaura D Wood

Abstract

This study aimed to identify risk factors for recurrence after pancreatic resection for intraductal papillary mucinous neoplasm (IPMN). Long-term follow-up data on recurrence after surgical resection for IPMN are currently lacking. Previous studies have presented mixed results on the role of margin status in risk of recurrence after surgical resection. A total of 126 patients that underwent resection for noninvasive IPMN were followed for a median of 9.5 years. Dedicated pathological and radiological reviews were performed to correlate clinical and pathological features (including detailed pathological features of the parenchymal margin) with recurrence after surgical resection. In addition, in a subset of 32 patients with positive margins, we determined the relationship between the margin and original IPMN using driver gene mutations identified by next-generation sequencing. Family history of pancreatic cancer and high-grade IPMN was identified as risk factors for recurrence in both uni- and multivariate analysis (adjusted hazard ratio 3.05 and 1.88, respectively). Although positive margin was not significantly associated with recurrence in our cohort, the size and grade of the dysplastic focus at the margin were significantly...Continue Reading

Citations

Apr 4, 2021·Journal of Clinical Medicine·Margaret G Keane, Elham Afghani
May 29, 2021·Langenbeck's Archives of Surgery·Naziheh AssarzadeganRalph H Hruban
Jun 9, 2021·Nature Reviews. Gastroenterology & Hepatology·Aatur D Singhi, Laura D Wood
Oct 23, 2021·Gastroenterology·Kjetil Søreide, Giovanni Marchegiani

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