The Impact of Company-Level ART Provision to a Mining Workforce in South Africa: A Cost-Benefit Analysis

PLoS Medicine
Gesine Meyer-RathPeter Vickerman

Abstract

HIV impacts heavily on the operating costs of companies in sub-Saharan Africa, with many companies now providing antiretroviral therapy (ART) programmes in the workplace. A full cost-benefit analysis of workplace ART provision has not been conducted using primary data. We developed a dynamic health-state transition model to estimate the economic impact of HIV and the cost-benefit of ART provision in a mining company in South Africa between 2003 and 2022. A dynamic health-state transition model, called the Workplace Impact Model (WIM), was parameterised with workplace data on workforce size, composition, turnover, HIV incidence, and CD4 cell count development. Bottom-up cost analyses from the employer perspective supplied data on inpatient and outpatient resource utilisation and the costs of absenteeism and replacement of sick workers. The model was fitted to workforce HIV prevalence and separation data while incorporating parameter uncertainty; univariate sensitivity analyses were used to assess the robustness of the model findings. As ART coverage increases from 10% to 97% of eligible employees, increases in survival and retention of HIV-positive employees and associated reductions in absenteeism and benefit payments lead to c...Continue Reading

References

Mar 5, 2004·Tropical Medicine & International Health : TM & IH·Matthew P FoxJonathon L Simon
Apr 13, 2004·AIDS·Sydney RosenJonathon L Simon
Dec 2, 2005·PLoS Medicine·Motasim BadriEduard J Beck
May 18, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Charles B HolmesRochelle P Walensky
Dec 7, 2006·Cost Effectiveness and Resource Allocation : C/E·Susan M ClearyAndrew M Boulle
Aug 21, 2007·AIDS·Salome CharalambousGavin J Churchyard
Aug 21, 2007·AIDS·Brian Brink, Jan Pienaar
Oct 24, 2007·Nursing Outlook·Elaine S Scott, Brenda L Cleary
Jun 12, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sydney RosenIan Sanne
Jul 18, 2008·Tropical Medicine & International Health : TM & IH·Sydney RosenIan Sanne
Feb 6, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Neil MartinsonCharles B Holmes
Jul 22, 2009·Annals of Internal Medicine·Rochelle P WalenskyUNKNOWN CEPAC (Cost-Effectiveness of Preventing AIDS Complications)-International Investigators
Jul 16, 2010·BMC Health Services Research·Susan Cleary, Di McIntyre
Sep 21, 2010·Lancet·Bradley Wagner, Sally Blower
Jan 7, 2011·PLoS Medicine·Rochelle P WalenskyUNKNOWN CEPAC-International Investigators
Jul 1, 2008·The Journal of Human Resources·Harsha ThirumurthyMarkus Goldstein
Aug 17, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gesine Meyer-RathWillem Daniel Francois Venter
Sep 28, 2012·AIDS·Gesine Meyer-RathSydney Rosen
Nov 29, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gesine Meyer-RathNeil Martinson

❮ Previous
Next ❯

Citations

Mar 30, 2017·BMC Health Services Research·Omar GalárragaRebecca K Papas
Apr 5, 2019·AIDS·Ranjeeta ThomasUNKNOWN HPTN 071 (PopART) Study Team
Nov 26, 2015·PLoS Medicine·Alexander C Tsai, Mark J Siedner
Oct 30, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Helena HuergaTom Ellman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.