The impact of concurrent Hashimoto thyroiditis on thyroid nodule cytopathology assessed by ultrasound-guided fine-needle aspiration cytology

Postgraduate Medicine
Fengqiu HuHui Huang

Abstract

Objective: Thyroid nodules are highly prevalent and a common clinical problem worldwide. How to identify the nature of a nodule is a major concern of clinicians. Fine needle aspiration cytology (FNAC) has an established role and is well-utilized in nodule management. However, the unsatisfactory nondiagnostic and indeterminate rates limit its usage and lead to some unnecessary surgery. Hashimoto thyroiditis (HT) is prevalently found concurrent with thyroid nodules. Whether HT can influence the accuracy of cytopathological diagnosis of nodules is still controversial.Methods: We collected medical records of 1,063 patients with thyroid nodules who had done FNAC in our hospital from 2015 to 2016. Thyroid function, anti-thyroid autoantibody levels, thyroid ultrasound records, and cytological and histopathological results of nodules were reviewed to analyze the impact of HT on FNAC outcome.Results: A total of 1,063 patients with an average age of 44 ± 13 years old were retrospectively reviewed for pathological and clinical data. Patients with different cytological diagnoses had comparable positive rates of anti-thyroid autoantibodies. One hundred patients were confirmed to have concurrent HT by histopathology after surgery. The overal...Continue Reading

References

May 18, 2010·Thyroid : Official Journal of the American Thyroid Association·Cüneyd AnilAlptekin Gursoy
Feb 24, 2012·Cytopathology : Official Journal of the British Society for Clinical Cytology·A MahajanR Nayar
Sep 12, 2012·Thyroid : Official Journal of the American Thyroid Association·Merica ShresthaHenry B Burch
Feb 26, 2013·The Journal of Clinical Endocrinology and Metabolism·Matthew T OlsonMartha A Zeiger
Sep 13, 2013·Annals of Internal Medicine·Edmund S CibasErik K Alexander
Aug 1, 2015·Endocrine Pathology·Domenico DamianiPhilippe Vielh
Jul 16, 2016·Nature Reviews. Endocrinology·Cari M Kitahara, Julie A Sosa
Oct 7, 2017·Thyroid : Official Journal of the American Thyroid Association·Markus EszlingerRalf Paschke
Mar 30, 2018·Thyroid : Official Journal of the American Thyroid Association·Massimo BongiovanniGerasimos P Sykiotis

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