The impact of COVID-19 in the management of AL amyloidosis and Immunoglobulin Deposition Disease: A single-center experience.

European Journal of Haematology
Holly LeeVictor H Jimenez-Zepeda

Abstract

Patients with AL amyloidosis and immunoglobulin deposition diseases (IDD) are vulnerable during the COVID-19 pandemic due to the immune compromise from the plasma cell disorder and therapy-related immune defects. We describe a local experience in providing care for patients with AL amyloidosis and IDD. Patient treatment and disease status since the beginning of the pandemic on March 11, 2020, as declared by WHO, were collected and analyzed. Ninety-six patients with AL amyloidosis and IDD were included. Four patients with IDD and 22 patients with systemic AL amyloidosis were receiving treatment during the pandemic. Since the pandemic, patients' treatments were discontinued if they achieved VGPR or better postinduction. Seven patients discontinued all treatment after achieving VGPR, and others required treatment modifications. 28 patients have been tested for COVID-19, and all tests have been negative. Three patients died since the pandemic, two from organ complications of systemic AL amyloidosis and one from an unrelated cause. The management of AL amyloidosis and IDD must be individualized on the clinical characteristics, centers' access to care under the pandemic restrictions, and the epidemiological aspects of the outbreak.

References

Oct 27, 2015·Advances in Therapy·Isabelle LousadaGiampaolo Merlini
Apr 25, 2017·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Eli MuchtarMorie A Gertz
Oct 21, 2017·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Luis Gerardo Rodríguez-LobatoJoan Bladé
Dec 10, 2017·Hematology·Giampaolo Merlini
Feb 19, 2020·The Lancet Oncology·Wenhua LiangJianxing He
Mar 25, 2020·International Journal of Antimicrobial Agents·Philippe GautretDidier Raoult
Apr 20, 2020·Acta Haematologica·Abdullah S Al SalehMorie A Gertz
Apr 26, 2020·Leukemia·Wenjuan HeRobert Peter Gale
Apr 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adarsh BhimrajYngve Falck-Ytter
May 27, 2020·The New England Journal of Medicine·Marc R Larochelle
Jun 1, 2020·Thérapie·M RoustitUNKNOWN French Society of Pharmacology and Therapeutics (SFPT)
Jun 2, 2020·Leukemia·Binod DhakalParameswaran Hari
Jun 2, 2020·British Journal of Haematology·Efstathios KastritisMeletios A Dimopoulos
Jun 9, 2020·JCO Global Oncology·Vassilis G GiannakoulisIlias I Siempos

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BETA
flow cytometry
biopsy

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SPSS
CyBorMe

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