The impact of cytokine responses in the intra- and extracellular signaling network of a traumatic injury

Cytokine
Alice A HanJonathan W Boyd

Abstract

Investigations of cellular responses involved in injury and repair processes have generated valuable information contributing to the advancement of wound healing and treatments. Intra- and extracellular regulators of healing mechanisms, such as cytokines, signaling proteins, and growth factors, have been described to possess significant roles in facilitating optimal recovery. This study explored a collection of 30 spatiotemporal responses comprised of cytokines (IL-1α, IL-1ß, IL-2, IL-6, TNF-α, MIP-1α), intracellular proteins (Akt, c-Jun, CREB, ERK1/2, JNK, MEK1, p38, p53, p90RSK), phosphorylated proteins (p-Akt, p-c-Jun, p-CREB, p-ERK1/2, p-GSK-3α/ß, p-HSP27, p-IκBα, p-JNK, p-MEK1, p-p38, p-p70S6K, p-p90RSK, p-STAT2, p-STAT3), and a protease (Caspase-3), measured in skeletal muscle tissue following a traumatic injury (rodent Gustilo IIIB fracture). To optimize the analysis of context-specific data sets, a network centrality parameter approach was used to assess the impact of each response in relation to all other measured responses. This approach identified proteins that were substantially amplified and potentially central in the wound healing network by evaluation of their corresponding centrality parameter, radiality. Networ...Continue Reading

Citations

Mar 14, 2018·International Journal of Molecular Sciences·F Andrea SassKatharina Schmidt-Bleek
Jan 9, 2020·Journal of Cachexia, Sarcopenia and Muscle·Carmen Sánchez-CastellanoAlfonso José Cruz-Jentoft
Jun 22, 2021·Military Medical Research·Peng-Tao WangYan-Hua Gong

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